Bench-Stable Electrophilic Reagents for the Direct Di- and Trifluoroethylthiolation of Indoles

Identificador:  imarina:9325555

Handle: https://hdl.handle.net/20.500.11797/imarina9325555

Autors:  Casasus, P; Mestre, J; Bernus, M; Castillon, S; Boutureira, O

Resum:
Two saccharine-based electrophilic reagents were developed for the direct introduction of SCH2CF3 and SCH2CF2H motifs via a C−S bond forming reaction. Their large-scale preparation and reactivity performance has been carefully examined, enabling access to a series of indoles through open-flask reactions. Sulfone and sulfoxide analogs (S(O)nCH2RF, n=1,2) are also accessible by sequential oxidation reactions. (Figure presented.).