Autor segons l'article: Espineira, S; Flores-Piñas, M; Chafino, S; Viladés, C; Negredo, E; Fernández-Arroyo, S; Mallolas, J; Villar, B; Moreno, S; Vidal, F; Rull, A; Peraire, J
Departament: Medicina i Cirurgia
Autor/s de la URV: Espineira Vazquez, Sonia / FERNANDEZ ARROYO, SALVADOR / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria / Villar Navas, Beatriz
Paraules clau: Transcriptomics T-cell-activation Proteomics Plhiv Metabolomics Immunological non-response Genomics transcriptomics risk recovery proteomics plhiv metabolomics infected patients individuals immunological non-response haplogroups cart antiretroviral therapy aids
Resum: Antiretroviral therapy (ART) induces persistent suppression of HIV-1 replication and gradual recovery of T-cell counts, and consequently, morbidity and mortality from HIV-related illnesses have been significantly reduced. However, in approximately 30% of people living with HIV (PLHIV) on ART, CD4+ T-cell counts fail to normalize despite ART and complete suppression of HIV viral load, resulting in severe immune dysfunction, which may represent an increased risk of clinical progression to AIDS and non-AIDS events as well as increased mortality. These patients are referred to as “immune inadequate responders”, “immunodiscordant responders” or “immune nonresponders (INR)”. The molecular mechanisms underlying poor CD4+ T-cell recovery are still unclear. In this sense, the use of omics sciences has shed light on possible factors involved in the activity and metabolic dysregulation of immune cells during the failure of CD4+ T-cell recovery in INR. Moreover, identification of key molecules by omics approaches allows for the proposal of potential biomarkers or therapeutic targets to improve CD4+ T-cell recovery and the quality of life of these patients. Hence, this review aimed to summarize the information obtained through different omics concerning the molecular factors and pathways associated with the INR phenotype to better understand the complexity of this immunological status in HIV infection.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Immunology and allergy Immunology Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: beatriz.villar@urv.cat joaquim.peraire@urv.cat consuelo.vilades@urv.cat francesc.vidal@urv.cat beatriz.villar@urv.cat sonia.espineira@estudiants.urv.cat
Identificador de l'autor: 0000-0001-7808-5479 0000-0002-2991-9593 0000-0002-6692-6186
Data d'alta del registre: 2024-01-13
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1228795/full
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Frontiers In Immunology. 14
Referència de l'ítem segons les normes APA: Espineira, S; Flores-Piñas, M; Chafino, S; Viladés, C; Negredo, E; Fernández-Arroyo, S; Mallolas, J; Villar, B; Moreno, S; Vidal, F; Rull, A; Peraire, (2023). Multi-omics in HIV: searching insights to understand immunological non-response in PLHIV. Frontiers In Immunology, 14(), -. DOI: 10.3389/fimmu.2023.1228795
DOI de l'article: 10.3389/fimmu.2023.1228795
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Tipus de publicació: Journal Publications
Repositori URV