Articles producció científica> Medicina i Cirurgia

Multi-omics in HIV: searching insights to understand immunological non-response in PLHIV

  • Datos identificativos

    Identificador: imarina:9329477
    Autores:
    Espineira, SFlores-Piñas, MChafino, SViladés, CNegredo, EFernández-Arroyo, SMallolas, JVillar, BMoreno, SVidal, FRull, APeraire, J
    Resumen:
    Antiretroviral therapy (ART) induces persistent suppression of HIV-1 replication and gradual recovery of T-cell counts, and consequently, morbidity and mortality from HIV-related illnesses have been significantly reduced. However, in approximately 30% of people living with HIV (PLHIV) on ART, CD4+ T-cell counts fail to normalize despite ART and complete suppression of HIV viral load, resulting in severe immune dysfunction, which may represent an increased risk of clinical progression to AIDS and non-AIDS events as well as increased mortality. These patients are referred to as “immune inadequate responders”, “immunodiscordant responders” or “immune nonresponders (INR)”. The molecular mechanisms underlying poor CD4+ T-cell recovery are still unclear. In this sense, the use of omics sciences has shed light on possible factors involved in the activity and metabolic dysregulation of immune cells during the failure of CD4+ T-cell recovery in INR. Moreover, identification of key molecules by omics approaches allows for the proposal of potential biomarkers or therapeutic targets to improve CD4+ T-cell recovery and the quality of life of these patients. Hence, this review aimed to summarize the information obtained through different omics concerning the molecular factors and pathways associated with the INR phenotype to better understand the complexity of this immunological status in HIV infection.
  • Otros:

    Autor según el artículo: Espineira, S; Flores-Piñas, M; Chafino, S; Viladés, C; Negredo, E; Fernández-Arroyo, S; Mallolas, J; Villar, B; Moreno, S; Vidal, F; Rull, A; Peraire, J
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Espineira Vazquez, Sonia / FERNANDEZ ARROYO, SALVADOR / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria / Villar Navas, Beatriz
    Palabras clave: Transcriptomics T-cell-activation Proteomics Plhiv Metabolomics Immunological non-response Genomics transcriptomics risk recovery proteomics plhiv metabolomics infected patients individuals immunological non-response haplogroups cart antiretroviral therapy aids
    Resumen: Antiretroviral therapy (ART) induces persistent suppression of HIV-1 replication and gradual recovery of T-cell counts, and consequently, morbidity and mortality from HIV-related illnesses have been significantly reduced. However, in approximately 30% of people living with HIV (PLHIV) on ART, CD4+ T-cell counts fail to normalize despite ART and complete suppression of HIV viral load, resulting in severe immune dysfunction, which may represent an increased risk of clinical progression to AIDS and non-AIDS events as well as increased mortality. These patients are referred to as “immune inadequate responders”, “immunodiscordant responders” or “immune nonresponders (INR)”. The molecular mechanisms underlying poor CD4+ T-cell recovery are still unclear. In this sense, the use of omics sciences has shed light on possible factors involved in the activity and metabolic dysregulation of immune cells during the failure of CD4+ T-cell recovery in INR. Moreover, identification of key molecules by omics approaches allows for the proposal of potential biomarkers or therapeutic targets to improve CD4+ T-cell recovery and the quality of life of these patients. Hence, this review aimed to summarize the information obtained through different omics concerning the molecular factors and pathways associated with the INR phenotype to better understand the complexity of this immunological status in HIV infection.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Immunology and allergy Immunology Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: beatriz.villar@urv.cat joaquim.peraire@urv.cat consuelo.vilades@urv.cat sonia.espineira@estudiants.urv.cat beatriz.villar@urv.cat francesc.vidal@urv.cat
    Identificador del autor: 0000-0001-7808-5479 0000-0002-2991-9593 0000-0002-6692-6186
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1228795/full
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Frontiers In Immunology. 14
    Referencia de l'ítem segons les normes APA: Espineira, S; Flores-Piñas, M; Chafino, S; Viladés, C; Negredo, E; Fernández-Arroyo, S; Mallolas, J; Villar, B; Moreno, S; Vidal, F; Rull, A; Peraire, (2023). Multi-omics in HIV: searching insights to understand immunological non-response in PLHIV. Frontiers In Immunology, 14(), -. DOI: 10.3389/fimmu.2023.1228795
    DOI del artículo: 10.3389/fimmu.2023.1228795
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Immunology,Immunology and Allergy
    Transcriptomics
    T-cell-activation
    Proteomics
    Plhiv
    Metabolomics
    Immunological non-response
    Genomics
    transcriptomics
    risk
    recovery
    proteomics
    plhiv
    metabolomics
    infected patients
    individuals
    immunological non-response
    haplogroups
    cart
    antiretroviral therapy
    aids
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Immunology and allergy
    Immunology
    Farmacia
    Engenharias iii
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
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