Autor segons l'article: Descamps-Solà M; Vilalta A; Jalsevac F; Blay MT; Rodríguez-Gallego E; Pinent M; Beltrán-Debón R; Terra X; Ardévol A
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Descamps Solà, Maria / Jalsevac, Florijan / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena / VILALTA CLEMENTE, ARANTXA
Codi de projecte: Grant agreement No. 945413
Paraules clau: Taste sensing Orthology Nutrient sensors Gut Extraoral tas2r
Resum: For decades bitter taste receptors (TAS2R) were thought to be located only in the mouth and to serve as sensors for nutrients and harmful substances. However, in recent years Tas2r have also been reported in extraoral tissues such as the skin, the lungs, and the intestine, where their function is still uncertain. To better understand the physiological role of these receptors, in this paper we focused on the intestine, an organ in which their activation may be similar to the receptors found in the mouth. We compare the relative presence of these receptors along the gastrointestinal tract in three main species of biomedical research (mice, rats and humans) using sequence homology. Current data from studies of rodents are scarce and while more data are available in humans, they are still deficient. Our results indicate, unexpectedly, that the reported expression profiles do not always coincide between species even if the receptors are orthologs. This may be due not only to evolutionary divergence of the species but also to their adaptation to different dietary patterns. Further studies are needed in order to develop an integrated vision of these receptors and their physiological functionality along the gastrointestinal tract.
Àrees temàtiques: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicina i Interdisciplinar Food science Endocrinology, diabetes and metabolism Educação física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: maria.descamps@urv.cat anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
Identificador de l'autor: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
Data d'alta del registre: 2024-08-03
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.frontiersin.org/articles/10.3389/fnut.2023.1215889/full
Programa de finançament: Marie Sklodowska-Curie Actions – European Union’s Horizon 2020 research and innovation programme
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Front Nutr. 10 1215889-
Referència de l'ítem segons les normes APA: Descamps-Solà M; Vilalta A; Jalsevac F; Blay MT; Rodríguez-Gallego E; Pinent M; Beltrán-Debón R; Terra X; Ardévol A (2023). Bitter taste receptors along the gastrointestinal tract: comparison between humans and rodents. Front Nutr, 10(), 1215889-. DOI: 10.3389/fnut.2023.1215889
Acrònim: MFP-Plus
DOI de l'article: 10.3389/fnut.2023.1215889
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2023
Acció del programa de finançament: Martí i Franquès COFUND Doctoral Programme
Tipus de publicació: Journal Publications