Autor según el artículo: Descamps-Solà M; Vilalta A; Jalsevac F; Blay MT; Rodríguez-Gallego E; Pinent M; Beltrán-Debón R; Terra X; Ardévol A
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Descamps Solà, Maria / Jalsevac, Florijan / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena / VILALTA CLEMENTE, ARANTXA
Código de proyecto: Grant agreement No. 945413
Palabras clave: Taste sensing Orthology Nutrient sensors Gut Extraoral tas2r
Resumen: For decades bitter taste receptors (TAS2R) were thought to be located only in the mouth and to serve as sensors for nutrients and harmful substances. However, in recent years Tas2r have also been reported in extraoral tissues such as the skin, the lungs, and the intestine, where their function is still uncertain. To better understand the physiological role of these receptors, in this paper we focused on the intestine, an organ in which their activation may be similar to the receptors found in the mouth. We compare the relative presence of these receptors along the gastrointestinal tract in three main species of biomedical research (mice, rats and humans) using sequence homology. Current data from studies of rodents are scarce and while more data are available in humans, they are still deficient. Our results indicate, unexpectedly, that the reported expression profiles do not always coincide between species even if the receptors are orthologs. This may be due not only to evolutionary divergence of the species but also to their adaptation to different dietary patterns. Further studies are needed in order to develop an integrated vision of these receptors and their physiological functionality along the gastrointestinal tract.
Áreas temáticas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicina i Interdisciplinar Food science Endocrinology, diabetes and metabolism Educação física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: maria.descamps@urv.cat anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
Identificador del autor: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fnut.2023.1215889/full
Programa de financiación: Marie Sklodowska-Curie Actions – European Union’s Horizon 2020 research and innovation programme
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Front Nutr. 10 1215889-
Referencia de l'ítem segons les normes APA: Descamps-Solà M; Vilalta A; Jalsevac F; Blay MT; Rodríguez-Gallego E; Pinent M; Beltrán-Debón R; Terra X; Ardévol A (2023). Bitter taste receptors along the gastrointestinal tract: comparison between humans and rodents. Front Nutr, 10(), 1215889-. DOI: 10.3389/fnut.2023.1215889
Acrónimo: MFP-Plus
DOI del artículo: 10.3389/fnut.2023.1215889
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Acción del progama de financiación: Martí i Franquès COFUND Doctoral Programme
Tipo de publicación: Journal Publications