Association between exposure to air pollution and blood lipids in the general population of Spain

Identificador:  imarina:9330542

Handle: https://hdl.handle.net/20.500.11797/imarina9330542

Autors:  Valdés, S; Doulatram-Gamgaram, V; Maldonado-Araque, C; Garcia-Escobar, E; Garcia-Serrano, S; Oualla-Bachiri, W; Garcia-Vivanco, M; Garrido, JL; Gil, V; Martin-Llorente, F; Calle-Pascual, A; Castaño, L; Delgado, E; Menéndez, E; Franch-Nadal, J; Gaztambide, S; Girbés, J; Chaves, FJ; Galán-García, JL; Aguilera-Venegas, G; Vallvé, JC; Amigó, N; Guardiola, M; Ribalta, J; Rojo-Martínez, G

Resum:
We aimed to assess the associations of exposure to air pollutants and standard and advanced lipoprotein measures, in a nationwide sample representative of the adult population of Spain.We included 4647 adults (>18 years), participants in the national, cross-sectional, population-based di@bet.es study, conducted in 2008-2010. Standard lipid measurements were analysed on an Architect C8000 Analyzer (Abbott Laboratories SA). Lipoprotein analysis was made by an advanced 1 H-NMR lipoprotein test (Liposcale®). Participants were assigned air pollution concentrations for particulate matter <10 μm (PM10 ), <2.5 μm (PM2.5 ) and nitrogen dioxide (NO2 ), corresponding to the health examination year, obtained by modelling combined with measurements taken at air quality stations (CHIMERE chemistry-transport model).In multivariate linear regression models, each IQR increase in PM10 , PM2.5 and NO2 was associated with 3.3%, 3.3% and 3% lower levels of HDL-c and 1.3%, 1.4% and 1.1% lower HDL particle (HDL-p) concentrations (p < .001 for all associations). In multivariate logistic regression, there was a significant association between PM10 , PM2.5 and NO2 concentrations and the odds of presenting low HDL-c (<40 mg/dL), low HDL-p (<p25) and higher LDL particle (LDL-p) concentrations (≥p75). In subgroup analyses there were stronger associations between PM10 and NO2 and low HDL-p in men (p for interaction .008 and .034), and between NO2 and low HDL-p in individuals with obesity (p for interaction .015).Our study shows an association between the exposure to air pollutants and blood lipids in the general population of Spain, suggesting a link to atherosclerosis.© 2023 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.