Repositori URV

Author, as appears in the article.: Valdés S; Doulatram-Gamgaram V; Maldonado-Araque C; García-Escobar E; García-Serrano S; Oualla-Bachiri W; García-Vivanco M; Garrido JL; Gil V; Martín-Llorente F; Calle-Pascual A; Castaño L; Delgado E; Menéndez E; Franch-Nadal J; Gaztambide S; Girbés J; Chaves FJ; Galán-García JL; Aguilera-Venegas G; Vallvé JC; Amigó N; Guardiola M; Ribalta J; Rojo-Martínez G

Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques

URV's Author/s: Guardiola Guionnet, Montserrat / Ribalta Vives, Josep / Vallvé Torrente, Joan Carles

Keywords: Triglyceride Lipoprotein Lipids Hdl Cholesterol Air pollution

Abstract: We aimed to assess the associations of exposure to air pollutants and standard and advanced lipoprotein measures, in a nationwide sample representative of the adult population of Spain.We included 4647 adults (>18 years), participants in the national, cross-sectional, population-based di@bet.es study, conducted in 2008-2010. Standard lipid measurements were analysed on an Architect C8000 Analyzer (Abbott Laboratories SA). Lipoprotein analysis was made by an advanced 1 H-NMR lipoprotein test (Liposcale®). Participants were assigned air pollution concentrations for particulate matter <10 μm (PM10 ), <2.5 μm (PM2.5 ) and nitrogen dioxide (NO2 ), corresponding to the health examination year, obtained by modelling combined with measurements taken at air quality stations (CHIMERE chemistry-transport model).In multivariate linear regression models, each IQR increase in PM10 , PM2.5 and NO2 was associated with 3.3%, 3.3% and 3% lower levels of HDL-c and 1.3%, 1.4% and 1.1% lower HDL particle (HDL-p) concentrations (p < .001 for all associations). In multivariate logistic regression, there was a significant association between PM10 , PM2.5 and NO2 concentrations and the odds of presenting low HDL-c (<40 mg/dL), low HDL-p (<p25) and higher LDL particle (LDL-p) concentrations (≥p75). In subgroup analyses there were stronger associations between PM10 and NO2 and low HDL-p in men (p for interaction .008 and .034), and between NO2 and low HDL-p in individuals with obesity (p for interaction .015).Our study shows an association between the exposure to air pollutants and blood lipids in the general population of Spain, suggesting a link to atherosclerosis.© 2023 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.

Thematic Areas: Saúde coletiva Odontología Nutrição Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: jc.vallve@urv.cat jc.vallve@urv.cat montse.guardiola@urv.cat josep.ribalta@urv.cat

Author identifier: 0000-0002-9696-7384 0000-0002-8879-4719

Record's date: 2024-08-03

Papper version: info:eu-repo/semantics/publishedVersion

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: European Journal Of Clinical Investigation. 54 (2): e14101-e14101

APA: Valdés S; Doulatram-Gamgaram V; Maldonado-Araque C; García-Escobar E; García-Serrano S; Oualla-Bachiri W; García-Vivanco M; Garrido JL; Gil V; Martín- (2024). Association between exposure to air pollution and blood lipids in the general population of Spain. European Journal Of Clinical Investigation, 54(2), e14101-e14101. DOI: 10.1111/eci.14101

Entity: Universitat Rovira i Virgili

Journal publication year: 2024

Publication Type: Journal Publications