Repositori URV

Identificador: imarina:9330686

Handle: https://hdl.handle.net/20.500.11797/imarina9330686

Autors:
Shyam, SGarcia-Gavilan, JFPaz-Graniel, IGaforio, JJMartinez-Gonzalez, MACorella, DMartinez, JAAlonso-Gomez, AMWaernberg, JVioque, JRomaguera, DLopez-Miranda, JEstruch, RTinahones, FJLapetra, JSerra-Majem, JLBueno-Cavanillas, ATur, JASanchez, VMPinto, XMatia-Martin, PVidal, JVazquez, CDaimiel, LRos, EFernandez-Aranda, FNishi, SKGarcia-Regata, OToledo, EAsensio, EMCastaner, OGarcia-Rios, ATorres-Collado, LGomez-Gracia, EZulet, MARuiz, NGCasas, RCano-Ibanez, NTojal-Sierra, LGomez-Perez, AMSorli, JVCinza-Sanjurjo, SMartin-Pelaez, SPena-Orihuela, PJOncina-Canovas, APerez-Araluce, RZomeno, MDChaplin, ADelgado-Rodriguez, MBabio, NFito, MSalas-Salvado, J

Resum:
Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).© 2023. BioMed Central Ltd., part of Springer Nature.