Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Identificador:  imarina:9330686

Handle: https://hdl.handle.net/20.500.11797/imarina9330686

Autores:  Shyam, Sangeetha; Garcia-Gavilan, Jesus Francisco; Paz-Graniel, Indira; Gaforio, Jose J; Martinez-Gonzalez, Miguel angel; Corella, Dolores; Martinez, J Alfredo; Alonso-Gomez, angel M; Waernberg, Julia; Vioque, Jesus; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J; Lapetra, Jose; Serra-Majem, J Luis; Bueno-Cavanillas, Aurora; Tur, Josep A; Sanchez, Vicente Martin; Pinto, Xavier; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Fernandez-Aranda, Fernando; Nishi, Stephanie K; Garcia-Regata, Oscar; Toledo, Estefania; Asensio, Eva M; Castaner, Olga; Garcia-Rios, Antonio; Torres-Collado, Laura; Gomez-Gracia, Enrique; Zulet, M Angeles; Ruiz, Nuria Goni; Casas, Rosa; Cano-Ibanez, Naomi; Tojal-Sierra, Lucas; Gomez-Perez, A M; Sorli, Jose V; Cinza-Sanjurjo, Sergio; Martin-Pelaez, Sandra; Pena-Orihuela, Patricia J; Oncina-Canovas, Alejandro; Perez-Araluce, Rafael; Zomeno, Maria Dolores; Chaplin, Alice; Delgado-Rodriguez, Miguel; Babio, Nancy; Fito, Montserrat; Salas-Salvado, Jordi

Resumen:
Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).© 2023. BioMed Central Ltd., part of Springer Nature.