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Advances in Chemical Protein Modification

  • Dades identificatives

    Identificador: imarina:9331865
    Autors:
    Boutureira, OmarBernardes, Goncalo J L
    Resum:
    Protein chemical modification is a problem-solving technique in research and technology. Modifications also occur in natural deteriorations. Generally these modifications are with the most reactive side chains and are predominantly oxidations, reductions, and nucleophilic and electrophilic substitutions. Deteriorations include peptide bond scissions, racemizations, β-eliminations, and formation of products by the reaction of proteins with added chemicals. Proteins are modified intentionally for structure-function relationship studies or for development of new and improved products. Although appearing quite varied, the techniques used in pharmacological, food and feed, or other industrial areas differ more operationally than from major differences in the levels of chemical sophistication that are used.
  • Altres:

    Autor segons l'article: Boutureira, Omar; Bernardes, Goncalo J L
    Departament: Química Analítica i Química Orgànica
    Autor/s de la URV: Boutureira Martín, Omar
    Paraules clau: Transition elements Thiol-ene reaction Site-specific conjugation Selective cysteine modification Proteins Pictet-spengler ligation Photoclick-chemistry Mediated protein Humans Directed tosyl chemistry Cross-metathesis Click chemistry Chemistry techniques, synthetic Azide-alkyne cycloaddition Animals Amino acids
    Resum: Protein chemical modification is a problem-solving technique in research and technology. Modifications also occur in natural deteriorations. Generally these modifications are with the most reactive side chains and are predominantly oxidations, reductions, and nucleophilic and electrophilic substitutions. Deteriorations include peptide bond scissions, racemizations, β-eliminations, and formation of products by the reaction of proteins with added chemicals. Proteins are modified intentionally for structure-function relationship studies or for development of new and improved products. Although appearing quite varied, the techniques used in pharmacological, food and feed, or other industrial areas differ more operationally than from major differences in the levels of chemical sophistication that are used.
    Àrees temàtiques: Química Materiais General medicine General chemistry Farmacia Engenharias iii Engenharias ii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Chemistry Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: omar.boutureira@urv.cat
    Identificador de l'autor: 0000-0002-0768-8309
    Data d'alta del registre: 2024-11-30
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Chemical Reviews. 115 (5): 2174-2195
    Referència de l'ítem segons les normes APA: Boutureira, Omar; Bernardes, Goncalo J L (2015). Advances in Chemical Protein Modification. Chemical Reviews, 115(5), 2174-2195. DOI: 10.1021/cr500399p
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2015
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Chemistry,Chemistry (Miscellaneous),Chemistry, Multidisciplinary
    Transition elements
    Thiol-ene reaction
    Site-specific conjugation
    Selective cysteine modification
    Proteins
    Pictet-spengler ligation
    Photoclick-chemistry
    Mediated protein
    Humans
    Directed tosyl chemistry
    Cross-metathesis
    Click chemistry
    Chemistry techniques, synthetic
    Azide-alkyne cycloaddition
    Animals
    Amino acids
    Química
    Materiais
    General medicine
    General chemistry
    Farmacia
    Engenharias iii
    Engenharias ii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Chemistry (all)
    Chemistry
    Biotecnología
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