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Advances in Chemical Protein Modification

  • Datos identificativos

    Identificador: imarina:9331865
    Autores:
    Boutureira, OmarBernardes, Goncalo J L
    Resumen:
    Protein chemical modification is a problem-solving technique in research and technology. Modifications also occur in natural deteriorations. Generally these modifications are with the most reactive side chains and are predominantly oxidations, reductions, and nucleophilic and electrophilic substitutions. Deteriorations include peptide bond scissions, racemizations, β-eliminations, and formation of products by the reaction of proteins with added chemicals. Proteins are modified intentionally for structure-function relationship studies or for development of new and improved products. Although appearing quite varied, the techniques used in pharmacological, food and feed, or other industrial areas differ more operationally than from major differences in the levels of chemical sophistication that are used.
  • Otros:

    Autor según el artículo: Boutureira, Omar; Bernardes, Goncalo J L
    Departamento: Química Analítica i Química Orgànica
    Autor/es de la URV: Boutureira Martín, Omar
    Palabras clave: Transition elements Thiol-ene reaction Site-specific conjugation Selective cysteine modification Proteins Pictet-spengler ligation Photoclick-chemistry Mediated protein Humans Directed tosyl chemistry Cross-metathesis Click chemistry Chemistry techniques, synthetic Azide-alkyne cycloaddition Animals Amino acids
    Resumen: Protein chemical modification is a problem-solving technique in research and technology. Modifications also occur in natural deteriorations. Generally these modifications are with the most reactive side chains and are predominantly oxidations, reductions, and nucleophilic and electrophilic substitutions. Deteriorations include peptide bond scissions, racemizations, β-eliminations, and formation of products by the reaction of proteins with added chemicals. Proteins are modified intentionally for structure-function relationship studies or for development of new and improved products. Although appearing quite varied, the techniques used in pharmacological, food and feed, or other industrial areas differ more operationally than from major differences in the levels of chemical sophistication that are used.
    Áreas temáticas: Química Materiais General medicine General chemistry Farmacia Engenharias iii Engenharias ii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Chemistry Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: omar.boutureira@urv.cat
    Identificador del autor: 0000-0002-0768-8309
    Fecha de alta del registro: 2024-11-30
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Chemical Reviews. 115 (5): 2174-2195
    Referencia de l'ítem segons les normes APA: Boutureira, Omar; Bernardes, Goncalo J L (2015). Advances in Chemical Protein Modification. Chemical Reviews, 115(5), 2174-2195. DOI: 10.1021/cr500399p
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2015
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Chemistry,Chemistry (Miscellaneous),Chemistry, Multidisciplinary
    Transition elements
    Thiol-ene reaction
    Site-specific conjugation
    Selective cysteine modification
    Proteins
    Pictet-spengler ligation
    Photoclick-chemistry
    Mediated protein
    Humans
    Directed tosyl chemistry
    Cross-metathesis
    Click chemistry
    Chemistry techniques, synthetic
    Azide-alkyne cycloaddition
    Animals
    Amino acids
    Química
    Materiais
    General medicine
    General chemistry
    Farmacia
    Engenharias iii
    Engenharias ii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Chemistry (all)
    Chemistry
    Biotecnología
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