Articles producció científica> Bioquímica i Biotecnologia

Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk

  • Dades identificatives

    Identificador: imarina:9366126
    Autors:
    Alam ABToledo-Atucha ERomaguera DAlonso-Gómez AMMartínez-Gonzalez MATojal-Sierra LMora MNMas-Llado CLi LGonzalez-Casanova ISalas-Salvadó JFitó MAlonso A
    Resum:
    Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.We studied 503 participants from the PREDIMED-Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]).In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargemen
  • Altres:

    Autor segons l'article: Alam AB; Toledo-Atucha E; Romaguera D; Alonso-Gómez AM; Martínez-Gonzalez MA; Tojal-Sierra L; Mora MN; Mas-Llado C; Li L; Gonzalez-Casanova I; Salas-Salvadó J; Fitó M; Alonso A
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Salas Salvadó, Jorge
    Paraules clau: Alcohol consumption Atrial fibrillation Atrial structure and function
    Resum: Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.We studied 503 participants from the PREDIMED-Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]).In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargement and worsening atrial function.URL: http://www.controlled-trials.com; Unique identifier: ISRCTN89898870.
    Àrees temàtiques: Biotecnología Cardiac & cardiovascular systems Cardiology and cardiovascular medicine Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Educação física Medicina i Medicina ii Nutrição Saúde coletiva
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: jordi.salas@urv.cat
    Identificador de l'autor: 0000-0003-2700-7459
    Data d'alta del registre: 2024-05-04
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.ahajournals.org/doi/10.1161/JAHA.123.031915
    Referència a l'article segons font original: Journal Of The American Heart Association. 13 (7): e031915-e031915
    Referència de l'ítem segons les normes APA: Alam AB; Toledo-Atucha E; Romaguera D; Alonso-Gómez AM; Martínez-Gonzalez MA; Tojal-Sierra L; Mora MN; Mas-Llado C; Li L; Gonzalez-Casanova I; Salas-S (2024). Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk. Journal Of The American Heart Association, 13(7), e031915-e031915. DOI: 10.1161/JAHA.123.031915
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1161/JAHA.123.031915
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2024
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine
    Alcohol consumption
    Atrial fibrillation
    Atrial structure and function
    Biotecnología
    Cardiac & cardiovascular systems
    Cardiology and cardiovascular medicine
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Educação física
    Medicina i
    Medicina ii
    Nutrição
    Saúde coletiva
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