Author, as appears in the article.: Alam AB; Toledo-Atucha E; Romaguera D; Alonso-Gómez AM; Martínez-Gonzalez MA; Tojal-Sierra L; Mora MN; Mas-Llado C; Li L; Gonzalez-Casanova I; Salas-Salvadó J; Fitó M; Alonso A
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Alcohol consumption Atrial fibrillation Atrial structure and function
Abstract: Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.We studied 503 participants from the PREDIMED-Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]).In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargement and worsening atrial function.URL: http://www.controlled-trials.com; Unique identifier: ISRCTN89898870.
Thematic Areas: Biotecnología Cardiac & cardiovascular systems Cardiology and cardiovascular medicine Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Educação física Medicina i Medicina ii Nutrição Saúde coletiva
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2024-05-04
Papper version: info:eu-repo/semantics/publishedVersion
Papper original source: Journal Of The American Heart Association. 13 (7): e031915-e031915
APA: Alam AB; Toledo-Atucha E; Romaguera D; Alonso-Gómez AM; Martínez-Gonzalez MA; Tojal-Sierra L; Mora MN; Mas-Llado C; Li L; Gonzalez-Casanova I; Salas-S (2024). Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk. Journal Of The American Heart Association, 13(7), e031915-e031915. DOI: 10.1161/JAHA.123.031915
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV