Autor segons l'article: van Gils, Veerle; Rizzo, Marianna; Cote, Jade; Viechtbauer, Wolfgang; Fanelli, Giuseppe; Salas-Salvado, Jordi; Wimberley, Theresa; Bullo, Monica; Fernandez-Aranda, Fernando; Dalsgaard, Soren; Visser, Pieter Jelle; Jansen, Willemijn J; Vos, Stephanie J B
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
Paraules clau: Vascular risk-factors Type 2 dm mellitus (t2dm) Tau proteins Tau Resistance (homa-ir Positron-emission tomography Positron emission tomography (pet) Peptide fragments Neurodegeneration Mini mental status examination (mmse) Mellitus Insulin-resistance Humans Homeostatic model assessment for insulin resistance (homa-ir) Homeostatic model assessment for insulin Glycemi Glycated hemoglobin (hba1c) Glycated haemoglobin (hba1c) Glucose Fasting blood glucose (fbg) Elderly persons Effect-size Diabetes mellitus Deposition Cognitive impairment Cognitive dysfunction Cerebrospinal-fluid biomarkers Cerebrospinal fluid (csf) Brain Biomarkers Amyloid-beta Amyloid beta-peptides Alzheimer disease
Resum: Conflicting evidence exists on the relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) biomarkers. Therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated hemoglobin, fasting blood glucose, insulin resistance indices) and DM status with AD biomarkers of amyloid-beta and tau measured by positron emission tomography or cerebrospinal fluid. We selected 37 studies from PubMed and Embase, including 11,694 individuals. More impaired glucose metabolism and DM status were associated with higher tau biomarkers (r=0.11[0.03-0.18], p=0.008; I2=68%), but were not associated with amyloid-beta biomarkers (r=-0.06[-0.13-0.01], p=0.08; I-2=81%). Meta-regression revealed that glucose metabolism and DM were specifically associated with tau biomarkers in population settings (p=0.001). Furthermore, more impaired glucose metabolism and DM status were associated with lower amyloid-beta biomarkers in memory clinic settings (p=0.004), and in studies with a higher prevalence of dementia (p
Àrees temàtiques: Psychology Psicología Neurosciences Neuropsychology and physiological psychology Medicina veterinaria Medicina ii Medicina i Interdisciplinar Engenharias ii Educação física Cognitive neuroscience Clinical neurology Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Behavioral sciences Behavioral neuroscience
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: monica.bullo@urv.cat jordi.salas@urv.cat
Identificador de l'autor: 0000-0002-0218-7046 0000-0003-2700-7459
Data d'alta del registre: 2025-02-24
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Neuroscience And Biobehavioral Reviews. 159 105604-
Referència de l'ítem segons les normes APA: van Gils, Veerle; Rizzo, Marianna; Cote, Jade; Viechtbauer, Wolfgang; Fanelli, Giuseppe; Salas-Salvado, Jordi; Wimberley, Theresa; Bullo, Monica; Fern (2024). The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis. Neuroscience And Biobehavioral Reviews, 159(), 105604-. DOI: 10.1016/j.neubiorev.2024.105604
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2024
Tipus de publicació: Journal Publications
Repositori URV