Autor según el artículo: van Gils, Veerle; Rizzo, Marianna; Cote, Jade; Viechtbauer, Wolfgang; Fanelli, Giuseppe; Salas-Salvado, Jordi; Wimberley, Theresa; Bullo, Monica; Fernandez-Aranda, Fernando; Dalsgaard, Soren; Visser, Pieter Jelle; Jansen, Willemijn J; Vos, Stephanie J B
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
Palabras clave: Vascular risk-factors Type 2 dm mellitus (t2dm) Tau Resistance (homa-ir Positron emission tomography (pet) Neurodegeneration Mini mental status examination (mmse) Mellitus Insulin-resistance Homeostatic model assessment for insulin resistance (homa-ir) Homeostatic model assessment for insulin Glycemi Glycated hemoglobin (hba1c) Glycated haemoglobin (hba1c) Fasting blood glucose (fbg) Elderly persons Effect-size Deposition Cognitive impairment Cerebrospinal-fluid biomarkers Cerebrospinal fluid (csf) Brain Amyloid-beta
Resumen: Conflicting evidence exists on the relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) biomarkers. Therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated hemoglobin, fasting blood glucose, insulin resistance indices) and DM status with AD biomarkers of amyloid-beta and tau measured by positron emission tomography or cerebrospinal fluid. We selected 37 studies from PubMed and Embase, including 11,694 individuals. More impaired glucose metabolism and DM status were associated with higher tau biomarkers (r=0.11[0.03-0.18], p=0.008; I2=68%), but were not associated with amyloid-beta biomarkers (r=-0.06[-0.13-0.01], p=0.08; I-2=81%). Meta-regression revealed that glucose metabolism and DM were specifically associated with tau biomarkers in population settings (p=0.001). Furthermore, more impaired glucose metabolism and DM status were associated with lower amyloid-beta biomarkers in memory clinic settings (p=0.004), and in studies with a higher prevalence of dementia (p
Áreas temáticas: Psychology Psicología Neurosciences Neuropsychology and physiological psychology Medicina veterinaria Medicina ii Medicina i Interdisciplinar Engenharias ii Educação física Cognitive neuroscience Clinical neurology Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Behavioral sciences Behavioral neuroscience
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: monica.bullo@urv.cat jordi.salas@urv.cat
Identificador del autor: 0000-0002-0218-7046 0000-0003-2700-7459
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Neuroscience And Biobehavioral Reviews. 159 105604-
Referencia de l'ítem segons les normes APA: van Gils, Veerle; Rizzo, Marianna; Cote, Jade; Viechtbauer, Wolfgang; Fanelli, Giuseppe; Salas-Salvado, Jordi; Wimberley, Theresa; Bullo, Monica; Fern (2024). The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis. Neuroscience And Biobehavioral Reviews, 159(), 105604-. DOI: 10.1016/j.neubiorev.2024.105604
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV