Author, as appears in the article.: van Gils, Veerle; Rizzo, Marianna; Cote, Jade; Viechtbauer, Wolfgang; Fanelli, Giuseppe; Salas-Salvado, Jordi; Wimberley, Theresa; Bullo, Monica; Fernandez-Aranda, Fernando; Dalsgaard, Soren; Visser, Pieter Jelle; Jansen, Willemijn J; Vos, Stephanie J B
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / Salas Salvadó, Jorge
Keywords: Vascular risk-factors; Type 2 dm mellitus (t2dm); Tau proteins; Tau; Resistance (homa-ir; Positron-emission tomography; Positron emission tomography (pet); Peptide fragments; Neurodegeneration; Mini mental status examination (mmse); Mellitus; Insulin-resistance; Humans; Homeostatic model assessment for insulin resistance (homa-ir); Homeostatic model assessment for insulin; Glycemi; Glycated hemoglobin (hba1c); Glycated haemoglobin (hba1c); Glucose; Fasting blood glucose (fbg); Elderly persons; Effect-size; Diabetes mellitus; Deposition; Cognitive impairment; Cognitive dysfunction; Cerebrospinal-fluid biomarkers; Cerebrospinal fluid (csf); Brain; Biomarkers; Amyloid-beta; Amyloid beta-peptides; Alzheimer disease
Abstract: Conflicting evidence exists on the relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) biomarkers. Therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated hemoglobin, fasting blood glucose, insulin resistance indices) and DM status with AD biomarkers of amyloid-beta and tau measured by positron emission tomography or cerebrospinal fluid. We selected 37 studies from PubMed and Embase, including 11,694 individuals. More impaired glucose metabolism and DM status were associated with higher tau biomarkers (r=0.11[0.03-0.18], p=0.008; I2=68%), but were not associated with amyloid-beta biomarkers (r=-0.06[-0.13-0.01], p=0.08; I-2=81%). Meta-regression revealed that glucose metabolism and DM were specifically associated with tau biomarkers in population settings (p=0.001). Furthermore, more impaired glucose metabolism and DM status were associated with lower amyloid-beta biomarkers in memory clinic settings (p=0.004), and in studies with a higher prevalence of dementia (p
Thematic Areas: Psychology; Psicología; Neurosciences; Neuropsychology and physiological psychology; Medicina veterinaria; Medicina ii; Medicina i; Interdisciplinar; Engenharias ii; Educação física; Cognitive neuroscience; Clinical neurology; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Behavioral sciences; Behavioral neuroscience
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: monica.bullo@urv.cat; jordi.salas@urv.cat
Record's date: 2025-02-24
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0149763424000733?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Neuroscience And Biobehavioral Reviews. 159 105604-
APA: van Gils, Veerle; Rizzo, Marianna; Cote, Jade; Viechtbauer, Wolfgang; Fanelli, Giuseppe; Salas-Salvado, Jordi; Wimberley, Theresa; Bullo, Monica; Fern (2024). The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis. Neuroscience And Biobehavioral Reviews, 159(), 105604-. DOI: 10.1016/j.neubiorev.2024.105604
Article's DOI: 10.1016/j.neubiorev.2024.105604
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV