Articles producció científica> Bioquímica i Biotecnologia

The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis

  • Identification data

    Identifier: imarina:9368621
    Authors:
    van Gils, VeerleRizzo, MariannaCote, JadeViechtbauer, WolfgangFanelli, GiuseppeSalas-Salvado, JordiWimberley, TheresaBullo, MonicaFernandez-Aranda, FernandoDalsgaard, SorenVisser, Pieter JelleJansen, Willemijn JVos, Stephanie J B
    Abstract:
    Conflicting evidence exists on the relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) biomarkers. Therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated hemoglobin, fasting blood glucose, insulin resistance indices) and DM status with AD biomarkers of amyloid-beta and tau measured by positron emission tomography or cerebrospinal fluid. We selected 37 studies from PubMed and Embase, including 11,694 individuals. More impaired glucose metabolism and DM status were associated with higher tau biomarkers (r=0.11[0.03-0.18], p=0.008; I2=68%), but were not associated with amyloid-beta biomarkers (r=-0.06[-0.13-0.01], p=0.08; I-2=81%). Meta-regression revealed that glucose metabolism and DM were specifically associated with tau biomarkers in population settings (p=0.001). Furthermore, more impaired glucose metabolism and DM status were associated with lower amyloid-beta biomarkers in memory clinic settings (p=0.004), and in studies with a higher prevalence of dementia (p
  • Others:

    Author, as appears in the article.: van Gils, Veerle; Rizzo, Marianna; Cote, Jade; Viechtbauer, Wolfgang; Fanelli, Giuseppe; Salas-Salvado, Jordi; Wimberley, Theresa; Bullo, Monica; Fernandez-Aranda, Fernando; Dalsgaard, Soren; Visser, Pieter Jelle; Jansen, Willemijn J; Vos, Stephanie J B
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Keywords: Vascular risk-factors Type 2 dm mellitus (t2dm) Tau proteins Tau Resistance (homa-ir Positron-emission tomography Positron emission tomography (pet) Peptide fragments Neurodegeneration Mini mental status examination (mmse) Mellitus Insulin-resistance Humans Homeostatic model assessment for insulin resistance (homa-ir) Homeostatic model assessment for insulin Glycemi Glycated hemoglobin (hba1c) Glycated haemoglobin (hba1c) Glucose Fasting blood glucose (fbg) Elderly persons Effect-size Diabetes mellitus Deposition Cognitive impairment Cognitive dysfunction Cerebrospinal-fluid biomarkers Cerebrospinal fluid (csf) Brain Biomarkers Amyloid-beta Amyloid beta-peptides Alzheimer disease
    Abstract: Conflicting evidence exists on the relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) biomarkers. Therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated hemoglobin, fasting blood glucose, insulin resistance indices) and DM status with AD biomarkers of amyloid-beta and tau measured by positron emission tomography or cerebrospinal fluid. We selected 37 studies from PubMed and Embase, including 11,694 individuals. More impaired glucose metabolism and DM status were associated with higher tau biomarkers (r=0.11[0.03-0.18], p=0.008; I2=68%), but were not associated with amyloid-beta biomarkers (r=-0.06[-0.13-0.01], p=0.08; I-2=81%). Meta-regression revealed that glucose metabolism and DM were specifically associated with tau biomarkers in population settings (p=0.001). Furthermore, more impaired glucose metabolism and DM status were associated with lower amyloid-beta biomarkers in memory clinic settings (p=0.004), and in studies with a higher prevalence of dementia (p
    Thematic Areas: Psychology Psicología Neurosciences Neuropsychology and physiological psychology Medicina veterinaria Medicina ii Medicina i Interdisciplinar Engenharias ii Educação física Cognitive neuroscience Clinical neurology Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Behavioral sciences Behavioral neuroscience
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: monica.bullo@urv.cat jordi.salas@urv.cat
    Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
    Record's date: 2025-02-24
    Paper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Paper original source: Neuroscience And Biobehavioral Reviews. 159 105604-
    APA: van Gils, Veerle; Rizzo, Marianna; Cote, Jade; Viechtbauer, Wolfgang; Fanelli, Giuseppe; Salas-Salvado, Jordi; Wimberley, Theresa; Bullo, Monica; Fern (2024). The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: A systematic review and meta-analysis. Neuroscience And Biobehavioral Reviews, 159(), 105604-. DOI: 10.1016/j.neubiorev.2024.105604
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Behavioral Neuroscience,Behavioral Sciences,Clinical Neurology,Cognitive Neuroscience,Neuropsychology and Physiological Psychology,Neurosciences
    Vascular risk-factors
    Type 2 dm mellitus (t2dm)
    Tau proteins
    Tau
    Resistance (homa-ir
    Positron-emission tomography
    Positron emission tomography (pet)
    Peptide fragments
    Neurodegeneration
    Mini mental status examination (mmse)
    Mellitus
    Insulin-resistance
    Humans
    Homeostatic model assessment for insulin resistance (homa-ir)
    Homeostatic model assessment for insulin
    Glycemi
    Glycated hemoglobin (hba1c)
    Glycated haemoglobin (hba1c)
    Glucose
    Fasting blood glucose (fbg)
    Elderly persons
    Effect-size
    Diabetes mellitus
    Deposition
    Cognitive impairment
    Cognitive dysfunction
    Cerebrospinal-fluid biomarkers
    Cerebrospinal fluid (csf)
    Brain
    Biomarkers
    Amyloid-beta
    Amyloid beta-peptides
    Alzheimer disease
    Psychology
    Psicología
    Neurosciences
    Neuropsychology and physiological psychology
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Engenharias ii
    Educação física
    Cognitive neuroscience
    Clinical neurology
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Behavioral sciences
    Behavioral neuroscience
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