A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats

Autor segons l'article: Baudin, Julio; Hernandez-Baixauli, Julia; Romero-Gimenez, Jordi; Yang, Hong; Mulero, Francisca; Puiggros, Francesc; Mardinoglu, Adil; Arola, Lluis; Caimari, Antoni

Departament: Bioquímica i Biotecnologia

Autor/s de la URV: Arola Fernández, Lluís / Arola Ferrer, Luis Maria / Baudin Luque, Julio Carlos

Paraules clau: Supplementatio; Serine; Oxidative stress; Obesity; Nutraceuticals; Nf-kappa-b; Menopause; Insulin-resistance; Inflammation; Immunometabolic health; Histidine; Food-intake; Expression; Elevated plus-maze; Cysteine; Complementary and alternative therapies; Complementary and alternative therapie; Cell function; Carnosine; Body-composition

Resum: Many women have sought alternative therapies to address menopause. Recently, a multi-ingredient supplement (MIS) containing L-histidine, L-carnosine, L-serine, and L-cysteine has been shown to be effective at ameliorating hepatic steatosis (HS) in ovariectomized (OVX) rats, a postmenopausal oestrogen deficiency model. Considering that HS frequently accompanies obesity, which often occurs during menopause, we aimed to investigate the effects of this MIS for 8 weeks in OVX rats. Twenty OVX rats were orally supplemented with either MIS (OVX-MIS) or vehicle (OVX). Ten OVX rats received vehicle orally along with subcutaneous injections of 17 beta-oestradiol (OVX-E2), whereas 10 rats underwent a sham operation and received oral and injected vehicles (control group). MIS consumption partly counteracted the fat mass accretion observed in OVX animals, leading to decreased total fat mass, adiposity index and retroperitoneal white adipose tissue (RWAT) adipocyte hypertrophy. OVX-MIS rats also displayed increased lean mass and lean/fat ratio, suggesting a healthier body composition, similar to the results reported for OVX-E2 animals. MIS consumption decreased the circulating levels of the proinflammatory marker CRP, the total cholesterol-to-HDL-cholesterol ratio and the leptin-to-adiponectin ratio, a biomarker of diabetes risk and metabolic syndrome. RWAT transcriptomics indicated that MIS favourably regulated genes involved in adipocyte structure and morphology, cell fate determination and differentiation, glucose/insulin homeostasis, inflammation, response to stress and oxidative phosphorylation, which may be mechanisms underlying the beneficial effects described for OVX-MIS rats. Our results pave the way for using this MIS formulation to improve the body composition and immunometabolic health of menopausal women.

Àrees temàtiques: Saúde coletiva; Química; Pharmacology & pharmacy; Pharmacology; Odontología; Medicine, research & experimental; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; Farmacia; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Biotecnología; Biodiversidade; Astronomia / física

Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/

Adreça de correu electrònic de l'autor: juliocarlos.baudin@estudiants.urv.cat; lluis.arola@estudiants.urv.cat; lluis.arola@estudiants.urv.cat; lluis.arola@urv.cat

Data d'alta del registre: 2025-01-28

Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion

Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0753332224012113

URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/

Referència a l'article segons font original: Biomedicine & Pharmacotherapy. 179 117326-

Referència de l'ítem segons les normes APA: Baudin, Julio; Hernandez-Baixauli, Julia; Romero-Gimenez, Jordi; Yang, Hong; Mulero, Francisca; Puiggros, Francesc; Mardinoglu, Adil; Arola, Lluis; Ca (2024). A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats. Biomedicine & Pharmacotherapy, 179(), 117326-. DOI: 10.1016/j.biopha.2024.117326

DOI de l'article: 10.1016/j.biopha.2024.117326

Entitat: Universitat Rovira i Virgili

Any de publicació de la revista: 2024

Tipus de publicació: Journal Publications