Articles producció científica> Bioquímica i Biotecnologia

A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats

  • Identification data

    Identifier: imarina:9380939
    Authors:
    Baudin, JulioHernandez-Baixauli, JuliaRomero-Gimenez, JordiYang, HongMulero, FranciscaPuiggros, FrancescMardinoglu, AdilArola, LluisCaimari, Antoni
    Abstract:
    Many women have sought alternative therapies to address menopause. Recently, a multi-ingredient supplement (MIS) containing L-histidine, L-carnosine, L-serine, and L-cysteine has been shown to be effective at ameliorating hepatic steatosis (HS) in ovariectomized (OVX) rats, a postmenopausal oestrogen deficiency model. Considering that HS frequently accompanies obesity, which often occurs during menopause, we aimed to investigate the effects of this MIS for 8 weeks in OVX rats. Twenty OVX rats were orally supplemented with either MIS (OVX-MIS) or vehicle (OVX). Ten OVX rats received vehicle orally along with subcutaneous injections of 17 beta-oestradiol (OVX-E2), whereas 10 rats underwent a sham operation and received oral and injected vehicles (control group). MIS consumption partly counteracted the fat mass accretion observed in OVX animals, leading to decreased total fat mass, adiposity index and retroperitoneal white adipose tissue (RWAT) adipocyte hypertrophy. OVX-MIS rats also displayed increased lean mass and lean/fat ratio, suggesting a healthier body composition, similar to the results reported for OVX-E2 animals. MIS consumption decreased the circulating levels of the proinflammatory marker CRP, the total cholesterol-to-HDL-cholesterol ratio and the leptin-to-adiponectin ratio, a biomarker of diabetes risk and metabolic syndrome. RWAT transcriptomics indicated that MIS favourably regulated genes involved in adipocyte structure and morphology, cell fate determination and differentiation, glucose/insulin homeostasis, inflammation, response to stress and oxidative phosphorylation, which may be mechanisms underlying the beneficial effects described for OVX-MIS rats. Our results pave the way for using this MIS formulation to improve the body composition and immunome
  • Others:

    Author, as appears in the article.: Baudin, Julio; Hernandez-Baixauli, Julia; Romero-Gimenez, Jordi; Yang, Hong; Mulero, Francisca; Puiggros, Francesc; Mardinoglu, Adil; Arola, Lluis; Caimari, Antoni
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Arola Ferrer, Luis Maria / Baudin Luque, Julio Carlos
    Keywords: Body-composition Carnosine Cell function Complementary and alternative therapie Complementary and alternative therapies Cysteine Elevated plus-maze Expression Food-intake Histidine Immunometabolic health Inflammation Insulin-resistance Menopause Nf-kappa-b Nutraceuticals Obesity Oxidative stress Serine Supplementatio
    Abstract: Many women have sought alternative therapies to address menopause. Recently, a multi-ingredient supplement (MIS) containing L-histidine, L-carnosine, L-serine, and L-cysteine has been shown to be effective at ameliorating hepatic steatosis (HS) in ovariectomized (OVX) rats, a postmenopausal oestrogen deficiency model. Considering that HS frequently accompanies obesity, which often occurs during menopause, we aimed to investigate the effects of this MIS for 8 weeks in OVX rats. Twenty OVX rats were orally supplemented with either MIS (OVX-MIS) or vehicle (OVX). Ten OVX rats received vehicle orally along with subcutaneous injections of 17 beta-oestradiol (OVX-E2), whereas 10 rats underwent a sham operation and received oral and injected vehicles (control group). MIS consumption partly counteracted the fat mass accretion observed in OVX animals, leading to decreased total fat mass, adiposity index and retroperitoneal white adipose tissue (RWAT) adipocyte hypertrophy. OVX-MIS rats also displayed increased lean mass and lean/fat ratio, suggesting a healthier body composition, similar to the results reported for OVX-E2 animals. MIS consumption decreased the circulating levels of the proinflammatory marker CRP, the total cholesterol-to-HDL-cholesterol ratio and the leptin-to-adiponectin ratio, a biomarker of diabetes risk and metabolic syndrome. RWAT transcriptomics indicated that MIS favourably regulated genes involved in adipocyte structure and morphology, cell fate determination and differentiation, glucose/insulin homeostasis, inflammation, response to stress and oxidative phosphorylation, which may be mechanisms underlying the beneficial effects described for OVX-MIS rats. Our results pave the way for using this MIS formulation to improve the body composition and immunometabolic health of menopausal women.
    Thematic Areas: Astronomia / física Biodiversidade Biotecnología Ciência da computação Ciência de alimentos Ciências agrárias i Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Educação física Enfermagem Engenharias ii Engenharias iii Farmacia Interdisciplinar Materiais Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Medicine, research & experimental Odontología Pharmacology Pharmacology & pharmacy Química Saúde coletiva
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: juliocarlos.baudin@estudiants.urv.cat lluis.arola@urv.cat
    Author identifier: 0000-0003-2767-1974 0000-0002-1016-4688
    Record's date: 2024-09-28
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0753332224012113
    Papper original source: Biomedicine & Pharmacotherapy. 179 117326-
    APA: Baudin, Julio; Hernandez-Baixauli, Julia; Romero-Gimenez, Jordi; Yang, Hong; Mulero, Francisca; Puiggros, Francesc; Mardinoglu, Adil; Arola, Lluis; Ca (2024). A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats. Biomedicine & Pharmacotherapy, 179(), 117326-. DOI: 10.1016/j.biopha.2024.117326
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.biopha.2024.117326
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Medicine, Research & Experimental,Pharmacology,Pharmacology & Pharmacy
    Body-composition
    Carnosine
    Cell function
    Complementary and alternative therapie
    Complementary and alternative therapies
    Cysteine
    Elevated plus-maze
    Expression
    Food-intake
    Histidine
    Immunometabolic health
    Inflammation
    Insulin-resistance
    Menopause
    Nf-kappa-b
    Nutraceuticals
    Obesity
    Oxidative stress
    Serine
    Supplementatio
    Astronomia / física
    Biodiversidade
    Biotecnología
    Ciência da computação
    Ciência de alimentos
    Ciências agrárias i
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Educação física
    Enfermagem
    Engenharias ii
    Engenharias iii
    Farmacia
    Interdisciplinar
    Materiais
    Medicina i
    Medicina ii
    Medicina iii
    Medicina veterinaria
    Medicine (miscellaneous)
    Medicine, research & experimental
    Odontología
    Pharmacology
    Pharmacology & pharmacy
    Química
    Saúde coletiva
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