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The Predictive Potential of C-Peptide in Differentiating Type 1 Diabetes From Type 2 Diabetes in an Outpatient Population in Abu Dhabi

  • Dades identificatives

    Identificador: imarina:9382515
    Autors:
    Iqbal, SajidAbu Jayyab, AbdulrahimAlrashdi, Ayah MohammadShujauddin, SyedClua-Espuny, Josep LluisReverte-Villarroya, Silvia
    Resum:
    Purpose: We aimed to investigate the predictive potential of plasma connecting peptide (C-peptide) in differentiating type 1 diabetes (T1D) from type 2 diabetes (T2D) and to inform evidence-based diabetes classification criteria. Methods: A retrospective review was performed of all the patients with diabetes visiting an outpatient diabetology, endocrinology, general practice and family medicine tertiary health care center between January 2016 and December 2021. Findings: Two hundred twelve individuals with diabetes were included, 85 (44.8%) with T1D and 127 (55.2%) with T2D. Mean (SD) age at diagnosis was 35.9 (15.1) years, and 112 (52.8%) men. Median (interquartile range [IQR]) duration of diabetes was 3.8 (3.0-4.5) years (T1D, 3.9 [3.5-4.6]; T2D, 3.4 [2.4-4.4]; P = 0.001). Body mass index was < 18.5 kg/m2 2 in 5 (2.5%) individuals (T1D, 5; T2D, none), 18.5 to < 25 kg/m2 2 in 57 (28.5%) (T1D, 32; T2D, 25), 25 to < 30 kg/m2 2 in 58 (29%) (T1D, 28; T2D, 30), and > 30 kg/m2 2 in 80 (40.0%) (T1D, 20; T2D, 60). Median (IQR) glycosylated hemoglobin was 7.4% (6.7%-8.5%) (T1D, 8.3% [7.2%-9.9%]; T2D, 7% [6.3%- 7.6%]; P = 0.0001). Median (IQR) C-peptide concentration was 0.59 nmol/L (0.01-1.14 nmol/L) (T1D, 0.01 nmol/L [0.003-0.05 nmol/L]; T2D, 1.03 nmol/L [0.70-1.44 nmol/L]; P = 0.0001). C-peptide concentration of
  • Altres:

    Autor segons l'article: Iqbal, Sajid; Abu Jayyab, Abdulrahim; Alrashdi, Ayah Mohammad; Shujauddin, Syed; Clua-Espuny, Josep Lluis; Reverte-Villarroya, Silvia
    Departament: Infermeria
    Autor/s de la URV: Reverté Villarroya, Silvia
    Paraules clau: Adults Ag Beta-cell function C-peptide Children Classification Diabetes mellitus Diagnosis Help Mellitus Pilot Predictive ability of c-peptide Prevalence Type 1 diabetes Type 2 diabete Type 2 diabetes Β-cell function
    Resum: Purpose: We aimed to investigate the predictive potential of plasma connecting peptide (C-peptide) in differentiating type 1 diabetes (T1D) from type 2 diabetes (T2D) and to inform evidence-based diabetes classification criteria. Methods: A retrospective review was performed of all the patients with diabetes visiting an outpatient diabetology, endocrinology, general practice and family medicine tertiary health care center between January 2016 and December 2021. Findings: Two hundred twelve individuals with diabetes were included, 85 (44.8%) with T1D and 127 (55.2%) with T2D. Mean (SD) age at diagnosis was 35.9 (15.1) years, and 112 (52.8%) men. Median (interquartile range [IQR]) duration of diabetes was 3.8 (3.0-4.5) years (T1D, 3.9 [3.5-4.6]; T2D, 3.4 [2.4-4.4]; P = 0.001). Body mass index was < 18.5 kg/m2 2 in 5 (2.5%) individuals (T1D, 5; T2D, none), 18.5 to < 25 kg/m2 2 in 57 (28.5%) (T1D, 32; T2D, 25), 25 to < 30 kg/m2 2 in 58 (29%) (T1D, 28; T2D, 30), and > 30 kg/m2 2 in 80 (40.0%) (T1D, 20; T2D, 60). Median (IQR) glycosylated hemoglobin was 7.4% (6.7%-8.5%) (T1D, 8.3% [7.2%-9.9%]; T2D, 7% [6.3%- 7.6%]; P = 0.0001). Median (IQR) C-peptide concentration was 0.59 nmol/L (0.01-1.14 nmol/L) (T1D, 0.01 nmol/L [0.003-0.05 nmol/L]; T2D, 1.03 nmol/L [0.70-1.44 nmol/L]; P = 0.0001). C-peptide concentration of
    Àrees temàtiques: Ciências biológicas i Ciências biológicas ii Engenharias iv Farmacia General medicine Interdisciplinar Medicina i Medicina ii Medicina iii Pharmacology Pharmacology & pharmacy Pharmacology (medical) Saúde coletiva
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: silvia.reverte@urv.cat
    Identificador de l'autor: 0000-0002-2052-9978
    Data d'alta del registre: 2024-10-05
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Referència a l'article segons font original: Clinical Therapeutics. 46 (9): 696-701
    Referència de l'ítem segons les normes APA: Iqbal, Sajid; Abu Jayyab, Abdulrahim; Alrashdi, Ayah Mohammad; Shujauddin, Syed; Clua-Espuny, Josep Lluis; Reverte-Villarroya, Silvia (2024). The Predictive Potential of C-Peptide in Differentiating Type 1 Diabetes From Type 2 Diabetes in an Outpatient Population in Abu Dhabi. Clinical Therapeutics, 46(9), 696-701. DOI: 10.1016/j.clinthera.2024.07.002
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2024
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Pharmacology,Pharmacology & Pharmacy,Pharmacology (Medical)
    Adults
    Ag
    Beta-cell function
    C-peptide
    Children
    Classification
    Diabetes mellitus
    Diagnosis
    Help
    Mellitus
    Pilot
    Predictive ability of c-peptide
    Prevalence
    Type 1 diabetes
    Type 2 diabete
    Type 2 diabetes
    Β-cell function
    Ciências biológicas i
    Ciências biológicas ii
    Engenharias iv
    Farmacia
    General medicine
    Interdisciplinar
    Medicina i
    Medicina ii
    Medicina iii
    Pharmacology
    Pharmacology & pharmacy
    Pharmacology (medical)
    Saúde coletiva
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