Author, as appears in the article.: Iqbal, Sajid; Abu Jayyab, Abdulrahim; Alrashdi, Ayah Mohammad; Shujauddin, Syed; Clua-Espuny, Josep Lluis; Reverte-Villarroya, Silvia
Department: Infermeria
URV's Author/s: Reverté Villarroya, Silvia / Sajid, Iqbal
Keywords: Β-cell function Type 2 diabetes Type 2 diabete Type 1 diabetes Retrospective studies Prevalence Predictive value of tests Predictive ability of c-peptide Pilot Outpatients Middle aged Mellitus Male Humans Help Glycated hemoglobin Female Diagnosis, differential Diagnosis Diabetes mellitus, type 2 Diabetes mellitus, type 1 Diabetes mellitus Classification Children C-peptide Biomarkers Beta-cell function Ag Adults Adult
Abstract: Purpose: We aimed to investigate the predictive potential of plasma connecting peptide (C-peptide) in differentiating type 1 diabetes (T1D) from type 2 diabetes (T2D) and to inform evidence-based diabetes classification criteria. Methods: A retrospective review was performed of all the patients with diabetes visiting an outpatient diabetology, endocrinology, general practice and family medicine tertiary health care center between January 2016 and December 2021. Findings: Two hundred twelve individuals with diabetes were included, 85 (44.8%) with T1D and 127 (55.2%) with T2D. Mean (SD) age at diagnosis was 35.9 (15.1) years, and 112 (52.8%) men. Median (interquartile range [IQR]) duration of diabetes was 3.8 (3.0-4.5) years (T1D, 3.9 [3.5-4.6]; T2D, 3.4 [2.4-4.4]; P = 0.001). Body mass index was < 18.5 kg/m2 2 in 5 (2.5%) individuals (T1D, 5; T2D, none), 18.5 to < 25 kg/m2 2 in 57 (28.5%) (T1D, 32; T2D, 25), 25 to < 30 kg/m2 2 in 58 (29%) (T1D, 28; T2D, 30), and > 30 kg/m2 2 in 80 (40.0%) (T1D, 20; T2D, 60). Median (IQR) glycosylated hemoglobin was 7.4% (6.7%-8.5%) (T1D, 8.3% [7.2%-9.9%]; T2D, 7% [6.3%- 7.6%]; P = 0.0001). Median (IQR) C-peptide concentration was 0.59 nmol/L (0.01-1.14 nmol/L) (T1D, 0.01 nmol/L [0.003-0.05 nmol/L]; T2D, 1.03 nmol/L [0.70-1.44 nmol/L]; P = 0.0001). C-peptide concentration of
Thematic Areas: Saúde coletiva Pharmacology (medical) Pharmacology & pharmacy Pharmacology Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Ciências biológicas ii Ciências biológicas i
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: silvia.reverte@urv.cat iqbal.sajid@estudiants.urv.cat
Author identifier: 0000-0002-2052-9978 0000-0003-0122-6485
Record's date: 2025-01-28
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Clinical Therapeutics. 46 (9): 696-701
APA: Iqbal, Sajid; Abu Jayyab, Abdulrahim; Alrashdi, Ayah Mohammad; Shujauddin, Syed; Clua-Espuny, Josep Lluis; Reverte-Villarroya, Silvia (2024). The Predictive Potential of C-Peptide in Differentiating Type 1 Diabetes From Type 2 Diabetes in an Outpatient Population in Abu Dhabi. Clinical Therapeutics, 46(9), 696-701. DOI: 10.1016/j.clinthera.2024.07.002
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV