Articles producció científica> Bioquímica i Biotecnologia

Combined supplementation with hesperidin, phytosterols and curcumin decreases adiposity and improves metabolic health in ovariectomized rats

  • Dades identificatives

    Identificador: imarina:9386414
    Autors:
    Baudin, JulioHernandez-Baixauli, JuliaQuesada-Vazquez, SergioMulero, FranciscaPuiggros, FrancescArola, LluisCaimari, Antoni
    Resum:
    In recent years many women have looked for alternative therapies to address menopause. Hesperidin, phytosterols and curcumin are bioactive compounds that can ameliorate some cardiovascular risk factors associated with menopause, although there are no data concerning the effects of their combined supplementation. We used ovariectomized (OVX) rats, a postmenopausal model with oestrogen deficiency, to evaluate whether supplementation with a multi-ingredient (MI) including hesperidin, phytosterols and curcumin for 57 days would display beneficial effects against fat mass accretion and metabolic disturbances associated with menopause. Twenty OVX rats were orally supplemented with either MI (OVX-MI) or vehicle (OVX). Furthermore, 10 OVX rats orally received the vehicle along with subcutaneous injections of 17 beta-oestradiol biweekly (OVX-E2), whereas 10 rats were sham operated and received oral and injected vehicles (control group; SH). MI supplementation partly counteracted the fat mass accretion observed in OVX animals, which was evidenced by decreased total fat mass, adiposity index, the weight of retroperitoneal, inguinal and mesenteric white adipose tissue (MWAT) depots and MWAT adipocyte hypertrophy. These effects were accompanied by a significant decrease in the circulating levels of leptin and the mRNA levels of the fatty acid uptake-related genes Lpl and Cd36 in MWAT. These results were very similar to those observed in OVX-E2 animals. OVX-MI rats also displayed a higher lean body mass, lean/fat mass ratio, adiponectin-to-leptin ratio and insulin sensitivity than their OVX counterparts. Our findings can pave the way for using this MI formulation as an alternative therapy to manage obesity and to improve the cardiometabolic health of menopausal women. In recent years
  • Altres:

    Autor segons l'article: Baudin, Julio; Hernandez-Baixauli, Julia; Quesada-Vazquez, Sergio; Mulero, Francisca; Puiggros, Francesc; Arola, Lluis; Caimari, Antoni
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Arola Fernández, Lluís / Arola Ferrer, Luis Maria / Baudin Luque, Julio Carlos
    Paraules clau: Adiponecti Adiposity Animals Bone loss Cardiovascular-disease Curcumin Dietary supplements Energy-expenditure Female Hesperidin Humans Inflammation Insulin-resistance Leptin Menopause Model Obesity Ovariectomy Phytosterols Rats Rats, sprague-dawley Rats, wistar
    Resum: In recent years many women have looked for alternative therapies to address menopause. Hesperidin, phytosterols and curcumin are bioactive compounds that can ameliorate some cardiovascular risk factors associated with menopause, although there are no data concerning the effects of their combined supplementation. We used ovariectomized (OVX) rats, a postmenopausal model with oestrogen deficiency, to evaluate whether supplementation with a multi-ingredient (MI) including hesperidin, phytosterols and curcumin for 57 days would display beneficial effects against fat mass accretion and metabolic disturbances associated with menopause. Twenty OVX rats were orally supplemented with either MI (OVX-MI) or vehicle (OVX). Furthermore, 10 OVX rats orally received the vehicle along with subcutaneous injections of 17 beta-oestradiol biweekly (OVX-E2), whereas 10 rats were sham operated and received oral and injected vehicles (control group; SH). MI supplementation partly counteracted the fat mass accretion observed in OVX animals, which was evidenced by decreased total fat mass, adiposity index, the weight of retroperitoneal, inguinal and mesenteric white adipose tissue (MWAT) depots and MWAT adipocyte hypertrophy. These effects were accompanied by a significant decrease in the circulating levels of leptin and the mRNA levels of the fatty acid uptake-related genes Lpl and Cd36 in MWAT. These results were very similar to those observed in OVX-E2 animals. OVX-MI rats also displayed a higher lean body mass, lean/fat mass ratio, adiponectin-to-leptin ratio and insulin sensitivity than their OVX counterparts. Our findings can pave the way for using this MI formulation as an alternative therapy to manage obesity and to improve the cardiometabolic health of menopausal women. In recent years many women have looked for alternative therapies to address menopause.
    Àrees temàtiques: Biochemistry & molecular biology Biotecnología Ciência de alimentos Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Educação física Farmacia Food science Food science & technology Interdisciplinar Materiais Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Nutrição Odontología Química Saúde coletiva Zootecnia / recursos pesqueiros
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: lluis.arola@urv.cat lluis.arola@estudiants.urv.cat lluis.arola@estudiants.urv.cat juliocarlos.baudin@estudiants.urv.cat
    Identificador de l'autor: 0000-0003-2767-1974 0000-0002-1016-4688
    Data d'alta del registre: 2024-10-12
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://pubs.rsc.org/en/content/articlelanding/2024/fo/d3fo05122f
    Referència a l'article segons font original: Food & Function. 15 (9): 4905-4924
    Referència de l'ítem segons les normes APA: Baudin, Julio; Hernandez-Baixauli, Julia; Quesada-Vazquez, Sergio; Mulero, Francisca; Puiggros, Francesc; Arola, Lluis; Caimari, Antoni (2024). Combined supplementation with hesperidin, phytosterols and curcumin decreases adiposity and improves metabolic health in ovariectomized rats. Food & Function, 15(9), 4905-4924. DOI: 10.1039/d3fo05122f
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1039/d3fo05122f
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2024
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Biochemistry & Molecular Biology,Food Science,Food Science & Technology,Medicine (Miscellaneous)
    Adiponecti
    Adiposity
    Animals
    Bone loss
    Cardiovascular-disease
    Curcumin
    Dietary supplements
    Energy-expenditure
    Female
    Hesperidin
    Humans
    Inflammation
    Insulin-resistance
    Leptin
    Menopause
    Model
    Obesity
    Ovariectomy
    Phytosterols
    Rats
    Rats, sprague-dawley
    Rats, wistar
    Biochemistry & molecular biology
    Biotecnología
    Ciência de alimentos
    Ciências agrárias i
    Ciências ambientais
    Ciências biológicas i
    Ciências biológicas ii
    Educação física
    Farmacia
    Food science
    Food science & technology
    Interdisciplinar
    Materiais
    Medicina i
    Medicina ii
    Medicina iii
    Medicina veterinaria
    Medicine (miscellaneous)
    Nutrição
    Odontología
    Química
    Saúde coletiva
    Zootecnia / recursos pesqueiros
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