Author, as appears in the article.: Marta Romeu; Laura Rubió; Vanessa Sánchez-Martos; Olga Castaner; Rafael de la Torre; Rosa M. Valls; Rosa Ras; Anna Pedret; Úrsula Catalán; María del Carmen López de las Hazas; María J. Motilva; Montserrat Fito; Rosa Solà; Montserrat Giralt
Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques
URV's Author/s: ROMEU FERRAN, MARTA; Laura Rubio; SÁNCHEZ MARTOS, VANESSA; Olga Castan¿er; Rafael de la Torre; VALLS ZAMORA, ROSA MARIA; Rosa Ras; PEDRET FIGUEROLA, ANNA; CATALÁN SANTOS, ÚRSULA; María del Carmen Lo¿pez de las Hazas; María J. Motilva; Montserrat Fito; SOLÀ ALBERICH, ROSA MARIA; GIRALT BATISTA, MONTSERRAT
Keywords: phenol enrichment thyme phenols virgin olive oil
Abstract: The effects of virgin olive oil (VOO) enriched with its own phenolic compounds (PC) and/or thyme PC on the protection against oxidative DNA damage and antioxidant endogenous enzymatic system (AEES) were estimated in 33 hyperlipidemic subjects after the consumption of VOO, VOO enriched with its own PC (FVOO), or VOO complemented with thyme PC (FVOOT). Compared to pre-intervention, 8-hydroxy-2′-deoxyguanosine (a marker for DNA damage) decreased in the FVOO intervention and to a greater extent in the FVOOT with a parallel significant increase in olive and thyme phenolic metabolites. Superoxide dismutase (AEES enzyme) significantly increased in the FVOO intervention and to a greater extent in the FVOOT with a parallel significant increase in thyme phenolic metabolites. When all three oils were compared, FVOOT appeared to have the greatest effect in protecting against oxidative DNA damage and improving AEES. The sustained intake of a FVOOT improves DNA protection against oxidation and AEES probably due to a greater bioavailability of thyme PC in hyperlipidemic subjects.
Research group: Farmacobiologia Cel.lular Unitat de Recerca de Lípids i Arteriosclerosi
Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0021-8561
Author identifier: orcid.org/0000-0002-2131-1858; N/D; N/D; N/D; N/D; N/D; N/D; orcid.org/0000-0002-5327-932X; N/D; orcid.org/0000-0001-8199-6724; N/D; orcid.org/0000-0002-1817-483X; orcid.org/0000-0002-8359-235X; orcid.org/0000-0002-7073-577X
Record's date: 2016-05-12
Last page: 1888
Journal volume: 64
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://pubs.acs.org/doi/10.1021/acs.jafc.5b04915
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1021/acs.jafc.5b04915
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
First page: 1879
Publication Type: Article Artículo Article
Repositori URV