Author, as appears in the article.: Camps, J.; Luciano-Mateo, F.; Hernández-Aguilera, A.; Cabre, N.; Fernández-Arroyo, S.; Lopez-Miranda, J.; Menendez, J.A.; Joven, J.
Department: Medicina i Cirurgia
URV's Author/s: CAMPS ANDREU, JORGE; Luciano-Mateo, F.; Hernández-Aguilera, A.; Cabre, N.; Fernández-Arroyo, S.; Lopez-Miranda, J.; Menendez, J.A.; JOVEN MARIED, JORGE
Keywords: obesity Energy intake Diabetes mellitus
Abstract: Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive intake of nutrients and drugs mimicking dietary effects and dietary restriction are the most successful manipulations targeting age-related pathways. Phenotypic heterogeneity and individual response to metabolic stressors are closely related food intake. Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially the way in which organismal bioenergetics remodel one-carbon metabolism. Metformin not only inhibits mitochondrial complex 1, modulating the metabolic response to nutrient intake, but also alters one-carbon metabolic pathways. Here, we discuss findings on the mechanism(s) of action of metformin with the potential for therapeutic interpretations.
Research group: Unitat de Recerca Biomèdica
Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2072-6643
Author identifier: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
Record's date: 2017-03-06
Journal volume: 9
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
First page: Art.num. 121
Publication Type: Article Artículo Article
Repositori URV