Articles producció científica> Ciències Mèdiques Bàsiques

Presynaptic muscarinic acetylcholine receptors and TrkB receptor cooperate in the elimination of redundant motor nerve terminals during development

  • Identification data

    Identifier: PC:2614
    Authors:
    Nadal, L.Garcia, N.Hurtado, E.Simó, A.Tomàs, M.Lanuza, M.A.Cilleros, V.Tomàs, J.
    Abstract:
    DOI: 10.3389/fnagi.2017.00024 URL: http://journal.frontiersin.org/article/10.3389/fnagi.2017.00024/full Filiació URV: SI
  • Others:

    Author, as appears in the article.: Nadal, L.; Garcia, N.; Hurtado, E.; Simó, A.; Tomàs, M.; Lanuza, M.A.; Cilleros, V.; Tomàs, J.
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: NADAL MAGRIÑÀ, LAURA; Garcia, N.; HURTADO CABALLERO, ERICA; SIMÓ OLLÉ, ANNA; TOMAS MARGINET, MARTA; LANUZA ESCOLANO, MARÍA ANGEL; CILLEROS MAÑÉ, VÍCTOR; Tomàs, J.
    Keywords: cholinergic synapses motor nerve terminal Neuromuscular junction
    Abstract: The development of the nervous system involves the overproduction of synapses but connectivity is refined by Hebbian activity-dependent axonal competition. The newborn skeletal muscle fibers are polyinnervated but, at the end of the competition process, some days later, become innervated by a single axon. We used quantitative confocal imaging of the autofluorescent axons from transgenic B6.Cg-Tg (Thy1-YFP)16 Jrs/J mice to investigate the possible cooperation of the muscarinic autoreceptors (mAChR, M1-, M2- and M4-subtypes) and the tyrosine kinase B (TrkB) receptor in the control of axonal elimination after the mice Levator auris longus (LAL) muscle had been exposed to several selective antagonist of the corresponding receptor pathways in vivo. Our previous results show that M1, M2 and TrkB signaling individually increase axonal loss rate around P9. Here we show that although the M1 and TrkB receptors cooperate and add their respective individual effects to increase axonal elimination rate even more, the effect of the M2 receptor is largely independent of both M1 and TrkB receptors. Thus both, cooperative and non-cooperative signaling mechanisms contribute to developmental synapse elimination.
    Research group: Unitat d'Histologia i Neurobiologia
    Thematic Areas: Ciències de la salut Ciencias de la salud Health sciences
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1663-4365
    Author identifier: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Record's date: 2017-03-21
    Journal volume: 9
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/articles/10.3389/fnagi.2017.00024/full
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.3389/fnagi.2017.00024
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    First page: Art.num. 24
    Publication Type: Article Artículo Article
  • Keywords:

    Sinapsi neuromuscular
    Terminacions nervioses
    Unió neuro-muscular
    cholinergic synapses
    motor nerve terminal
    Neuromuscular junction
    Ciències de la salut
    Ciencias de la salud
    Health sciences
    1663-4365
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