Articles producció científica> Ciències Mèdiques Bàsiques

Presynaptic muscarinic acetylcholine receptors and TrkB receptor cooperate in the elimination of redundant motor nerve terminals during development

  • Datos identificativos

    Identificador: PC:2614
    Autores:
    Nadal, L.Garcia, N.Hurtado, E.Simó, A.Tomàs, M.Lanuza, M.A.Cilleros, V.Tomàs, J.
    Resumen:
    DOI: 10.3389/fnagi.2017.00024 URL: http://journal.frontiersin.org/article/10.3389/fnagi.2017.00024/full Filiació URV: SI
  • Otros:

    Autor según el artículo: Nadal, L.; Garcia, N.; Hurtado, E.; Simó, A.; Tomàs, M.; Lanuza, M.A.; Cilleros, V.; Tomàs, J.
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: NADAL MAGRIÑÀ, LAURA; Garcia, N.; HURTADO CABALLERO, ERICA; SIMÓ OLLÉ, ANNA; TOMAS MARGINET, MARTA; LANUZA ESCOLANO, MARÍA ANGEL; CILLEROS MAÑÉ, VÍCTOR; Tomàs, J.
    Palabras clave: cholinergic synapses motor nerve terminal Neuromuscular junction
    Resumen: The development of the nervous system involves the overproduction of synapses but connectivity is refined by Hebbian activity-dependent axonal competition. The newborn skeletal muscle fibers are polyinnervated but, at the end of the competition process, some days later, become innervated by a single axon. We used quantitative confocal imaging of the autofluorescent axons from transgenic B6.Cg-Tg (Thy1-YFP)16 Jrs/J mice to investigate the possible cooperation of the muscarinic autoreceptors (mAChR, M1-, M2- and M4-subtypes) and the tyrosine kinase B (TrkB) receptor in the control of axonal elimination after the mice Levator auris longus (LAL) muscle had been exposed to several selective antagonist of the corresponding receptor pathways in vivo. Our previous results show that M1, M2 and TrkB signaling individually increase axonal loss rate around P9. Here we show that although the M1 and TrkB receptors cooperate and add their respective individual effects to increase axonal elimination rate even more, the effect of the M2 receptor is largely independent of both M1 and TrkB receptors. Thus both, cooperative and non-cooperative signaling mechanisms contribute to developmental synapse elimination.
    Grupo de investigación: Unitat d'Histologia i Neurobiologia
    Áreas temáticas: Ciències de la salut Ciencias de la salud Health sciences
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1663-4365
    Identificador del autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
    Fecha de alta del registro: 2017-03-21
    Volumen de revista: 9
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fnagi.2017.00024/full
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.3389/fnagi.2017.00024
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Página inicial: Art.num. 24
    Tipo de publicación: Article Artículo Article
  • Palabras clave:

    Sinapsi neuromuscular
    Terminacions nervioses
    Unió neuro-muscular
    cholinergic synapses
    motor nerve terminal
    Neuromuscular junction
    Ciències de la salut
    Ciencias de la salud
    Health sciences
    1663-4365
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