Author, as appears in the article.: Simó, J.M.; Gallifa, I.F.; Aguilera, A.H.; Heredia, A.G.; Cabré, N.; Mateo, F.L.; Paredero, V.M.; Camps, J.; Joven, J.
Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: SIMÓ SISÓ, JOSÉ MARIA; Gallifa, I.F.; Aguilera, A.H.; Heredia, A.G.; Cabré, N.; Mateo, F.L.; MARTÍN PAREDERO, VICENTE; CAMPS ANDREU, JORGE; JOVEN MARIED, JORGE
Keywords: Galectin-3 F2-isoprostanes atherosclerosis
Abstract: Galectin-3 is a modulator of oxidative stress, inflammation, and fibrogenesis involved in the pathogenesis of vascular diseases. The present study sought to characterize, in patients with peripheral artery disease (PAD), the localization of galectin-3 in arterial tissue, and to analyze the relationships between the circulating levels of galectin-3 and oxidative stress and inflammation. It also sought to compare the diagnostic accuracy of galectin-3 with that of other biochemical markers of this disease. We analyzed femoral or popliteal arteries from 50 PAD patients, and four control arteries. Plasma from 86 patients was compared with that from 72 control subjects. We observed differences in the expression of galectin-3 in normal arteries, and arteries from patients with PAD, with a displacement of the expression from the adventitia to the media, and the intima. In addition, plasma galectin-3 concentration was increased in PAD patients, and correlated with serologic markers of oxidative stress (F2-isoprostanes), and inflammation [chemokine (C–C motif) ligand 2, C-reactive protein, β-2-microglobulin]. We conclude that the determination of galectin-3 has good diagnostic accuracy in the assessment of PAD and compares well with other analytical parameters currently in use.
Research group: Unitat de Recerca Biomèdica
Thematic Areas: Health sciences Ciencias de la salud Ciències de la salut
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1661-6596
Author identifier: ; ; ; ; ; ; 0000-0002-2740-5847; ; 0000-0003-2749-4541
Record's date: 2017-05-26
Journal volume: 18
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: http://www.mdpi.com/1422-0067/18/5/973
Funding program: european; FEDER; PI15/00285 european; FEDER; PI11/00130 european; FEDER; PI11/02817
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3390/ijms18050973
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
First page: 973
Publication Type: Article Artículo Article