Recognition and Sensing of Creatinine

Identifier:  PC:3244

Handle: https://hdl.handle.net/20.500.11797/PC3244

Authors:  Guinovart, T.; Herández-Alonso, D.; Adriaenssens, L.; Blondeau, P.; Martínez-Belmonte, M.; Rius, F.X.; Andrade, F.J.; Ballester, P.

Abstract:
Current methods for creatinine quantification present significant drawbacks when aiming to combine accuracy, simplicity and affordability. Here, we report an unprecedented synthetic receptor, a mono-phosphonate aryl-extended calix[4]pyrrole, displaying remarkable affinity for creatinine and the creatininium cation. The receptor works by including the guests in its deep and polar aromatic cavity and establishing directional interactions in three dimensions. When incorporated into a suitable polymeric membrane, this molecule acts as an ionophore, playing the key role in a highly sensitive and selective potentiometric sensor suitable for the determination of creatinine in biological fluids such as urine or plasma in an accurate.