Articles producció científica> Ciències Mèdiques Bàsiques

Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth

  • Identification data

    Identifier: imarina:2620848
    Authors:
    Martinez-Perez, BrunoEjarque, MiriamGutierrez, CristinaNunez-Roa, CatalinaRoche, KellyVila-Bedmar, RocioBallesteros, MonicaRedondo-Angulo, IbonPlanavila, AnnaVillarroya, FrancescVendrell, JoanFernandez-Veledo, SoniaMegia, Ana
    Abstract:
    Angiopoietin-like protein 8 (ANGPTL8), a protein implicated in lipid and glucose homeostasis, is present only in mammals, suggesting that it is involved in processes unique to these vertebrates such as pregnancy and homeothermy. We explored the role of ANGPTL8 in maternal-fetal crosstalk and its relationship with newborn adiposity. In a longitudinal analysis of healthy pregnant women, ANGPTL8 levels decreased progressively during pregnancy although remained higher than levels in the postpartum period. In a cross-sectional observational study of women with or without gestational diabetes mellitus (GDM), and their offspring, ANGPTL8 levels were higher in venous cord blood than those in maternal blood and were significantly lower in GDM patients than those in healthy women. Infants small for gestational age and with low-fat mass had the highest ANGPTL8 cord blood levels. Studies in vitro revealed that ANGPTL8 was secreted by brown adipocytes and its expression was increased in experimental models of white-to-brown fat conversion. In addition, ANGPTL8 induced the expression of markers of brown adipocytes. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition.Copyright © 2016 Elsevier Inc. All rights reserved.
  • Others:

    Author, as appears in the article.: Martinez-Perez, Bruno; Ejarque, Miriam; Gutierrez, Cristina; Nunez-Roa, Catalina; Roche, Kelly; Vila-Bedmar, Rocio; Ballesteros, Monica; Redondo-Angulo, Ibon; Planavila, Anna; Villarroya, Francesc; Vendrell, Joan; Fernandez-Veledo, Sonia; Megia, Ana;
    Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    URV's Author/s: Fernandez Veledo, Sonia / Megía Colet, Ana / Vendrell Ortega, Juan José
    Keywords: Obesity Lipid-metabolism Insulin-resistance Gestational diabetes-mellitus Fat Fasting plasma-glucose Cord blood irisin Circulating betatrophin levels Birth-weight Beta-cell proliferation
    Abstract: Angiopoietin-like protein 8 (ANGPTL8), a protein implicated in lipid and glucose homeostasis, is present only in mammals, suggesting that it is involved in processes unique to these vertebrates such as pregnancy and homeothermy. We explored the role of ANGPTL8 in maternal-fetal crosstalk and its relationship with newborn adiposity. In a longitudinal analysis of healthy pregnant women, ANGPTL8 levels decreased progressively during pregnancy although remained higher than levels in the postpartum period. In a cross-sectional observational study of women with or without gestational diabetes mellitus (GDM), and their offspring, ANGPTL8 levels were higher in venous cord blood than those in maternal blood and were significantly lower in GDM patients than those in healthy women. Infants small for gestational age and with low-fat mass had the highest ANGPTL8 cord blood levels. Studies in vitro revealed that ANGPTL8 was secreted by brown adipocytes and its expression was increased in experimental models of white-to-brown fat conversion. In addition, ANGPTL8 induced the expression of markers of brown adipocytes. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition.Copyright © 2016 Elsevier Inc. All rights reserved.
    Research group: Grup de Recerca Biomèdica HJ23
    Thematic Areas: Saúde coletiva Public health, environmental and occupational health Physiology (medical) Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Medical laboratory technology Interdisciplinar General medicine Farmacia Ciências biológicas ii Ciências biológicas i Ciências ambientais Biochemistry (medical)
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 19315244
    Author's mail: sonia.fernandez@urv.cat ana.megia@urv.cat juanjose.vendrell@urv.cat
    Author identifier: 0000-0003-2906-3788 0000-0002-5101-9452 0000-0002-6994-6115
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.translationalres.com/article/S1931-5244(16)30105-0/fulltext
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Translational Research. 178 1-12
    APA: Martinez-Perez, Bruno; Ejarque, Miriam; Gutierrez, Cristina; Nunez-Roa, Catalina; Roche, Kelly; Vila-Bedmar, Rocio; Ballesteros, Monica; Redondo-Angul (2016). Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth. Translational Research, 178(), 1-12. DOI: 10.1016/j.trsl.2016.06.012
    Article's DOI: 10.1016/j.trsl.2016.06.012
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry (Medical),Medical Laboratory Technology,Medicine (Miscellaneous),Medicine, General & Internal,Medicine, Research & Experimental,Physiology (Medical),Public Health, Environmental and Occupational Health
    Obesity
    Lipid-metabolism
    Insulin-resistance
    Gestational diabetes-mellitus
    Fat
    Fasting plasma-glucose
    Cord blood irisin
    Circulating betatrophin levels
    Birth-weight
    Beta-cell proliferation
    Saúde coletiva
    Public health, environmental and occupational health
    Physiology (medical)
    Medicine, research & experimental
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Medical laboratory technology
    Interdisciplinar
    General medicine
    Farmacia
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Biochemistry (medical)
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