Autor según el artículo: Martinez-Perez, Bruno; Ejarque, Miriam; Gutierrez, Cristina; Nunez-Roa, Catalina; Roche, Kelly; Vila-Bedmar, Rocio; Ballesteros, Monica; Redondo-Angulo, Ibon; Planavila, Anna; Villarroya, Francesc; Vendrell, Joan; Fernandez-Veledo, Sonia; Megia, Ana
Departamento: Medicina i Cirurgia; Ciències Mèdiques Bàsiques
Autor/es de la URV: Fernandez Veledo, Sonia / Megía Colet, Ana / Vendrell Ortega, Juan José
Palabras clave: Obesity; Lipid-metabolism; Insulin-resistance; Gestational diabetes-mellitus; Fat; Fasting plasma-glucose; Cord blood irisin; Circulating betatrophin levels; Birth-weight; Beta-cell proliferation
Resumen: Angiopoietin-like protein 8 (ANGPTL8), a protein implicated in lipid and glucose homeostasis, is present only in mammals, suggesting that it is involved in processes unique to these vertebrates such as pregnancy and homeothermy. We explored the role of ANGPTL8 in maternal-fetal crosstalk and its relationship with newborn adiposity. In a longitudinal analysis of healthy pregnant women, ANGPTL8 levels decreased progressively during pregnancy although remained higher than levels in the postpartum period. In a cross-sectional observational study of women with or without gestational diabetes mellitus (GDM), and their offspring, ANGPTL8 levels were higher in venous cord blood than those in maternal blood and were significantly lower in GDM patients than those in healthy women. Infants small for gestational age and with low-fat mass had the highest ANGPTL8 cord blood levels. Studies in vitro revealed that ANGPTL8 was secreted by brown adipocytes and its expression was increased in experimental models of white-to-brown fat conversion. In addition, ANGPTL8 induced the expression of markers of brown adipocytes. The high levels of ANGPTL8 found in fetal life together with its relationship with newborn adiposity and brown adipose tissue point to ANGPTL8 as a potential new player in the modulation of the thermogenic machinery during the fetal-neonatal transition.Copyright © 2016 Elsevier Inc. All rights reserved.
Grupo de investigación: Grup de Recerca Biomèdica HJ23
Áreas temáticas: Saúde coletiva; Public health, environmental and occupational health; Physiology (medical); Medicine, research & experimental; Medicine, general & internal; Medicine (miscellaneous); Medicina veterinaria; Medicina ii; Medicina i; Medical laboratory technology; Interdisciplinar; General medicine; Farmacia; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Biochemistry (medical)
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 19315244
Direcció de correo del autor: sonia.fernandez@urv.cat; ana.megia@urv.cat; jvortega@iispv.cat
Fecha de alta del registro: 2025-02-18
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.translationalres.com/article/S1931-5244(16)30105-0/fulltext
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Translational Research. 178 1-12
Referencia de l'ítem segons les normes APA: Martinez-Perez, Bruno; Ejarque, Miriam; Gutierrez, Cristina; Nunez-Roa, Catalina; Roche, Kelly; Vila-Bedmar, Rocio; Ballesteros, Monica; Redondo-Angul (2016). Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: a brown adipose tissue-derived endocrine factor with a potential role in fetal growth. Translational Research, 178(), 1-12. DOI: 10.1016/j.trsl.2016.06.012
DOI del artículo: 10.1016/j.trsl.2016.06.012
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Tipo de publicación: Journal Publications
Repositori URV