Articles producció científica> Ciències Mèdiques Bàsiques

Crohn's Disease Disturbs the Immune Properties of Human Adipose-Derived Stem Cells Related to Inflammasome Activation

  • Identification data

    Identifier: imarina:3084963
    Authors:
    Serena C., Keiran N., Madeira A., Maymó-Masip E., Ejarque M., Terrón-Puig M., Espin E., Martí M., Borruel N., Guarner F., Menacho M., Zorzano A., Millan M., Fernández-Veledo S., Vendrell J.
    Abstract:
    Crohn's disease (CD) is characterized by the expansion of mesenteric fat, also known as "creeping fat." We explored the plasticity and immune properties of adipose-derived stem cells (ASCs) in the context of CD as potential key players in the development of creeping fat. Mesenteric CD-derived ASCs presented a more proliferative, inflammatory, invasive, and phagocytic phenotype than equivalent cells from healthy donors, irrespective of the clinical stage. Remarkably, ASCs from the subcutaneous depot of patients with CD also showed an activated immune response that was associated with a reduction in their immunosuppressive properties. The invasive phenotype of mesenteric CD ASCs was governed by an inflammasome-mediated inflammatory state since blocking inflammasome signaling, mainly the secretion of interleukin-1?, reversed this characteristic. Thus, CD alters the biological functions of ASCs as adipocyte precursors, but also their immune properties. Selection of ASCs with the best immunomodulatory properties is advocated for the success of cell-based therapies.Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
  • Others:

    Author, as appears in the article.: Serena C., Keiran N., Madeira A., Maymó-Masip E., Ejarque M., Terrón-Puig M., Espin E., Martí M., Borruel N., Guarner F., Menacho M., Zorzano A., Millan M., Fernández-Veledo S., Vendrell J.
    Department: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
    URV's Author/s: Fernandez Veledo, Sonia / Keiran Fernandez, Noelia Elisabeth / Maymo Masip, Elsa / Serena Perelló, Carolina / Terrón Puig, Margarida Maria / Vendrell Ortega, Juan José
    Keywords: Regulatory t cell Regulatory t cell Phagocytosis Migration Mesenchymal stem cells Lymphocytes Invasion Interleukin 1b Immunity Creeping fat Cell therapy phagocytosis migration mesenchymal stem cells lymphocytes invasion interleukin 1b immunity creeping fat cell therapy
    Abstract: Crohn's disease (CD) is characterized by the expansion of mesenteric fat, also known as "creeping fat." We explored the plasticity and immune properties of adipose-derived stem cells (ASCs) in the context of CD as potential key players in the development of creeping fat. Mesenteric CD-derived ASCs presented a more proliferative, inflammatory, invasive, and phagocytic phenotype than equivalent cells from healthy donors, irrespective of the clinical stage. Remarkably, ASCs from the subcutaneous depot of patients with CD also showed an activated immune response that was associated with a reduction in their immunosuppressive properties. The invasive phenotype of mesenteric CD ASCs was governed by an inflammasome-mediated inflammatory state since blocking inflammasome signaling, mainly the secretion of interleukin-1?, reversed this characteristic. Thus, CD alters the biological functions of ASCs as adipocyte precursors, but also their immune properties. Selection of ASCs with the best immunomodulatory properties is advocated for the success of cell-based therapies.Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
    Thematic Areas: Medicina i Genetics Developmental biology Cell biology Cell & tissue engineering Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 22136711
    Author's mail: carolina.serena@urv.cat elsa.maymo@urv.cat margaridamaria.terron@estudiants.urv.cat sonia.fernandez@urv.cat juanjose.vendrell@urv.cat
    Author identifier: 0000-0002-9133-3120 0000-0003-2906-3788 0000-0002-6994-6115
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30324-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213671117303247%3Fshowall%3Dtrue
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Stem Cell Reports. 9 (4): 1109-1123
    APA: Serena C., Keiran N., Madeira A., Maymó-Masip E., Ejarque M., Terrón-Puig M., Espin E., Martí M., Borruel N., Guarner F., Menacho M., Zorzano A., Mill (2017). Crohn's Disease Disturbs the Immune Properties of Human Adipose-Derived Stem Cells Related to Inflammasome Activation. Stem Cell Reports, 9(4), 1109-1123. DOI: 10.1016/j.stemcr.2017.07.014
    Article's DOI: 10.1016/j.stemcr.2017.07.014
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Cell & Tissue Engineering,Cell Biology,Developmental Biology,Genetics
    Regulatory t cell
    Regulatory t cell
    Phagocytosis
    Migration
    Mesenchymal stem cells
    Lymphocytes
    Invasion
    Interleukin 1b
    Immunity
    Creeping fat
    Cell therapy
    phagocytosis
    migration
    mesenchymal stem cells
    lymphocytes
    invasion
    interleukin 1b
    immunity
    creeping fat
    cell therapy
    Medicina i
    Genetics
    Developmental biology
    Cell biology
    Cell & tissue engineering
    Biochemistry
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