Articles producció científica> Ciències Mèdiques Bàsiques

Crohn's Disease Disturbs the Immune Properties of Human Adipose-Derived Stem Cells Related to Inflammasome Activation

  • Datos identificativos

    Identificador: imarina:3084963
    Handle: http://hdl.handle.net/20.500.11797/imarina3084963
  • Autores:

    Serena C., Keiran N., Madeira A., Maymó-Masip E., Ejarque M., Terrón-Puig M., Espin E., Martí M., Borruel N., Guarner F., Menacho M., Zorzano A., Millan M., Fernández-Veledo S., Vendrell J.
  • Otros:

    Autor según el artículo: Serena C., Keiran N., Madeira A., Maymó-Masip E., Ejarque M., Terrón-Puig M., Espin E., Martí M., Borruel N., Guarner F., Menacho M., Zorzano A., Millan M., Fernández-Veledo S., Vendrell J.
    Departamento: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
    Autor/es de la URV: Fernandez Veledo, Sonia / Maymo Masip, Elsa / Vendrell Ortega, Juan José
    Palabras clave: Regulatory t cell Regulatory t cell Phagocytosis Migration Mesenchymal stem cells Lymphocytes Invasion Interleukin 1b Immunity Creeping fat Cell therapy phagocytosis migration mesenchymal stem cells lymphocytes invasion interleukin 1b immunity creeping fat cell therapy
    Resumen: Crohn's disease (CD) is characterized by the expansion of mesenteric fat, also known as "creeping fat." We explored the plasticity and immune properties of adipose-derived stem cells (ASCs) in the context of CD as potential key players in the development of creeping fat. Mesenteric CD-derived ASCs presented a more proliferative, inflammatory, invasive, and phagocytic phenotype than equivalent cells from healthy donors, irrespective of the clinical stage. Remarkably, ASCs from the subcutaneous depot of patients with CD also showed an activated immune response that was associated with a reduction in their immunosuppressive properties. The invasive phenotype of mesenteric CD ASCs was governed by an inflammasome-mediated inflammatory state since blocking inflammasome signaling, mainly the secretion of interleukin-1?, reversed this characteristic. Thus, CD alters the biological functions of ASCs as adipocyte precursors, but also their immune properties. Selection of ASCs with the best immunomodulatory properties is advocated for the success of cell-based therapies.Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
    Áreas temáticas: Medicina i Genetics Developmental biology Cell biology Cell & tissue engineering Biochemistry
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 22136711
    Direcció de correo del autor: sonia.fernandez@urv.cat elsa.maymo@urv.cat juanjose.vendrell@urv.cat
    Identificador del autor: 0000-0003-2906-3788 0000-0002-9133-3120 0000-0002-6994-6115
    Fecha de alta del registro: 2023-02-18
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30324-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213671117303247%3Fshowall%3Dtrue
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Stem Cell Reports. 9 (4): 1109-1123
    Referencia de l'ítem segons les normes APA: Serena C., Keiran N., Madeira A., Maymó-Masip E., Ejarque M., Terrón-Puig M., Espin E., Martí M., Borruel N., Guarner F., Menacho M., Zorzano A., Mill (2017). Crohn's Disease Disturbs the Immune Properties of Human Adipose-Derived Stem Cells Related to Inflammasome Activation. Stem Cell Reports, 9(4), 1109-1123. DOI: 10.1016/j.stemcr.2017.07.014
    DOI del artículo: 10.1016/j.stemcr.2017.07.014
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry,Cell & Tissue Engineering,Cell Biology,Developmental Biology,Genetics
    Regulatory t cell
    Regulatory t cell
    Phagocytosis
    Migration
    Mesenchymal stem cells
    Lymphocytes
    Invasion
    Interleukin 1b
    Immunity
    Creeping fat
    Cell therapy
    phagocytosis
    migration
    mesenchymal stem cells
    lymphocytes
    invasion
    interleukin 1b
    immunity
    creeping fat
    cell therapy
    Medicina i
    Genetics
    Developmental biology
    Cell biology
    Cell & tissue engineering
    Biochemistry
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