Author, as appears in the article.: Schreiber, Elga; Garcia, Tania; Sharma, Raju Prasad; Torrente, Margarita; Domingo, Jose Luis; Gomez, Mercedes
Department: Ciències Mèdiques Bàsiques Psicologia Bioquímica i Biotecnologia
URV's Author/s: Domingo Roig, José Luis / Garcia Soldevila, Tània / Gómez Arnaiz, María Mercedes / Torrente Torné, Margarita
Keywords: Trace-elements Testis Testes Redox status Rats, sprague-dawley Rats Pregnant-women Peanut oil Partition-coefficients Parabens Paraben concentrations Oxidative stress N-butylparaben (n-butp) Male Lipid peroxidation In-vitro Glutathione reductase Glutathione peroxidase Glutathione Endocrine disruptors Catalase Calcium Butylparaben Butyl paraben Bisphenol-a Biomarkers Arachis Antioxidants Antioxidant system Animals testes rats peanut oil oxidative stress
Abstract: © 2019 Elsevier Ltd This study was aimed at determining if oxidative stress imbalance in testes of rats occurs after n-butylparaben (n-ButP) exposure. Young male Sprague-Dawley rats were subcutaneously treated with n-ButP during one spermatogenic cycle (57 days) at 0 (control-oil), 150, 300 and 600 mg/kg/d with peanut oil as vehicle. A non-vehicle control group was also included. Antioxidant enzyme activities (superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase) and levels of reduced and oxidized glutathione were measured in testes. Lipid peroxidation and H2O2 concentrations were also assessed. Results showed an increase of oxidative stress in oil-treated groups, excepting 600 mg/kg/d, suggesting oxidative stress due to peanut oil. A possible antioxidant effect due to n-ButP and its metabolites was suggested at 600 mg/kg/d, the only group not showing oxidative stress. An increase of calcium concentration in testes was also observed. On the other hand, a physiologically-based pharmacokinetic (PBPK) model was developed and the concentrations of n-ButP and its metabolites were simulated in plasma and testes. The peak concentration (Cmax) in testes was found slightly higher than that in plasma. The current results indicate that peanut oil can cause oxidative stress while high doses of n-ButP can act as antioxidant agent in testes.
Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Author's mail: joseluis.domingo@urv.cat margarita.torrente@urv.cat
Author identifier: 0000-0001-6647-9470 0000-0002-8901-6345
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Food And Chemical Toxicology. 131 (110573): 110573-
APA: Schreiber, Elga; Garcia, Tania; Sharma, Raju Prasad; Torrente, Margarita; Domingo, Jose Luis; Gomez, Mercedes (2019). Oxidative stress in testes of rats exposed to n-butylparaben. Food And Chemical Toxicology, 131(110573), 110573-. DOI: 10.1016/j.fct.2019.110573
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
Publication Type: Journal Publications
Repositori URV