Articles producció científicaEnginyeria Electrònica, Elèctrica i Automàtica

Aptamer-Based Nanoporous Anodic Alumina Interferometric Biosensor for Real-Time Thrombin Detection

  • Identification data

    Identifier:  imarina:6003795
    Handle: https://hdl.handle.net/20.500.11797/imarina6003795
    Authors:  Pol, Laura; Karen Acosta, Laura; Ferre-Borrull, Josep; Marsal, Lluis F; Marsal, Lluis F
    Abstract:
    Aptamer biosensors are one of the most powerful techniques in biosensing. Achieving the best platform to use in aptamer biosensors typically includes crucial chemical modifications that enable aptamer immobilization on the surface in the most efficient manner. These chemical modifications must be well defined. In this work we propose nanoporous anodic alumina (NAA) chemically modified with streptavidin as a platform for aptamer immobilization. The immobilization of biotinylated thrombin binding aptamer (TBA) was monitored in real time by means of reflective interferometric spectroscopy (RIfS). The study has permitted to characterize in real time the path to immobilize TBA on the inner pore walls of NAA. Furthermore, this study provides an accurate label-free method to detect thrombin in real-time with high affinity and specificity.

  • Others:

    Link to the original source: https://www.mdpi.com/1424-8220/19/20/4543
    APA: Pol, Laura; Karen Acosta, Laura; Ferre-Borrull, Josep; Marsal, Lluis F; Marsal, Lluis F (2019). Aptamer-Based Nanoporous Anodic Alumina Interferometric Biosensor for Real-Time Thrombin Detection. SENSORS, 19(20), 4543-. DOI: 10.3390/s19204543
    Paper original source: SENSORS. 19 (20): 4543-
    Article's DOI: 10.3390/s19204543
    Journal publication year: 2019-10-02
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2026-04-25
    URV's Author/s: Acosta Capilla, Laura Karen / Ferré Borrull, José / Marsal Garví, Luis Francisco / POL AIRA, LAURA
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    ISSN: 14248220
    Author, as appears in the article.: Pol, Laura; Karen Acosta, Laura; Ferre-Borrull, Josep; Marsal, Lluis F; Marsal, Lluis F
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Journal volume: 19
    e-ISSN: 1424-8220
    Thematic Areas: Zootecnia / recursos pesqueiros, Química, Medicine (miscellaneous), Medicina veterinaria, Medicina iii, Medicina ii, Medicina i, Materiais, Matemática / probabilidade e estatística, Linguística e literatura, Letras / linguística, Interdisciplinar, Instruments & instrumentation, Instrumentation, Information systems, Geografía, Geociências, Farmacia, Engineering, electrical & electronic, Engenharias iv, Engenharias iii, Engenharias ii, Engenharias i, Electrochemistry, Electrical and electronic engineering, Educação física, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Ciências ambientais, Ciências agrárias i, Ciência de alimentos, Ciência da computação, Chemistry, analytical, Biotecnología, Biodiversidade, Biochemistry, Atomic and molecular physics, and optics, Astronomia / física, Arquitetura, urbanismo e design, Analytical chemistry
    Author's mail: laurakaren.acosta@urv.cat, josep.ferre@urv.cat, lluis.marsal@urv.cat

  • Keywords:

    Thrombin aptamer
    Thrombin
    Streptavidin
    Selection
    Rifs
    Perspective
    Nanoporous anodic alumina
    Nanopores
    Molecules
    Limit of detection
    Interferometry
    Electrodes
    Electrochemical detection
    Biosensing techniques
    Biosensing
    Bind
    Aptamers
    nucleotide
    Aluminum oxide
    Analytical Chemistry
    Atomic and Molecular Physics
    and Optics
    Biochemistry
    Chemistry
    Analytical
    Electrical and Electronic Engineering
    Electrochemistry
    Engineering
    Electrical & Electronic
    Information Systems
    Instrumentation
    Instruments & Instrumentation
    Medicine (Miscellaneous)
    Zootecnia / recursos pesqueiros
    Química
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Linguística e literatura
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
    Arquitetura
    urbanismo e design

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