e-ISSN: 1638-6183
Project code: 713679
Keywords: Women Serum Reus-tarragona birth cohort Red blood cell folate Polymorphisms Miscarriage Microbiological assay Metabolism Maternal homocysteine Homocysteine History Folate Early-pregnancy Early pregnancy Conception red blood cell folate miscarriage homocysteine early pregnancy
Record's date: 2023-10-07
Papper version: info:eu-repo/semantics/acceptedVersion
Papper original source: Biochimie. 173 62-67
APA: Cavallé-Busquets P; Inglès-Puig M; Fernandez-Ballart JD; Haro-Barceló J; Rojas-Gómez A; Ramos-Rodriguez C; Ballesteros M; Meyer K; Ueland PM; Murphy M (2020). Moderately elevated first trimester fasting plasma total homocysteine is associated with increased probability of miscarriage. The Reus-Tarragona Birth Cohort Study. Biochimie, 173(), 62-67. DOI: 10.1016/j.biochi.2020.01.008
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Acronym: MFP-COFUND
Publication Type: Journal Publications
Author, as appears in the article.: Cavallé-Busquets P; Inglès-Puig M; Fernandez-Ballart JD; Haro-Barceló J; Rojas-Gómez A; Ramos-Rodriguez C; Ballesteros M; Meyer K; Ueland PM; Murphy MM
Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: Ballesteros Pérez, Monica / Cavallé Busquets, Pere / Fernández Ballart, Joan Domènech / Haro Barceló, Júlia / Murphy, Michelle / Ramos Rodríguez, Carla / Rojas Gómez, Alejandra
Abstract: © 2020 The association between elevated early pregnancy fasting plasma total homocysteine (tHcy) and miscarriage risk was investigated prospectively in participants (n = 544) from the Reus-Tarragona Birth Cohort study. Pregnancy was confirmed before 12 gestational weeks (GW) by ultrasound scan and a fasting blood sample collected. Pregnancies with complications other than miscarriages were excluded. Miscarriages were diagnosed by ultrasound scan and gestational age at the time of miscarriage estimated by embryo size, where possible. Cases in which blood samples were collected more than a week after the miscarriage, or the miscarriage was of known cause, were excluded. Fasting plasma folate, vitamin B12, tHcy, cotinine (biomarker of smoking), red blood cell (RBC) folate, MTHFR 677C > T (rs1801133) and SLC19A1 80G>A (rs1051266) genotypes were determined. The exposed group consisted of participants with first trimester tHcy ≥ P90 (7.1 μmol/L) (n = 57) and unexposed of those with tHcy < P90 (n = 487). Adherence to folic acid supplement recommendations, plasma folate, plasma vitamin B12, RBC folate and prevalence of optimal RBC folate status (≥ 906 μmol/L) were lower in the exposed compared to unexposed group. The prevalences of the MTHFR 677 TT genotype and miscarriage were higher in the exposed group. The relative risks (95% CI) of pregnancy ending in miscarriage were 2.5 (1.1, 5.7) and 2.1 (1.0, 4.5) for participants in the high tHcy and suboptimal RBC folate groups (compared to the reference groups) respectively. Adherence to folic acid supplement recommendations was positively associated, while the MTHFR 677 TT versus CC genotype and smoking versus non-smoking were negatively associated, with RBC folate status.
Thematic Areas: Zootecnia / recursos pesqueiros Química Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Engenharias iv Engenharias ii Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 03009084
Author's mail: monica.ballesteros@urv.cat carla.ramos@urv.cat pere.cavalleb@urv.cat michelle.murphy@urv.cat carla.ramos@urv.cat alejandra.rojas@urv.cat alejandra.rojas@urv.cat alejandra.rojas@urv.cat
Author identifier: 0000-0002-6304-6204 0000-0003-4427-2852 0000-0003-4427-2852 0000-0003-4427-2852
Paper data publication: 18 january 2020
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0300908420300109?via%3Dihub
Funding program: European Union Horizon 2020
Article's DOI: 10.1016/j.biochi.2020.01.008
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Funding program action: Marie Skłodowska-Curie