e-ISSN: 1638-6183
Código de proyecto: 713679
Palabras clave: Women Serum Reus-tarragona birth cohort Red blood cell folate Polymorphisms Miscarriage Microbiological assay Metabolism Maternal homocysteine Homocysteine History Folate Early-pregnancy Early pregnancy Conception red blood cell folate miscarriage homocysteine early pregnancy
Fecha de alta del registro: 2023-10-07
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Referencia al articulo segun fuente origial: Biochimie. 173 62-67
Referencia de l'ítem segons les normes APA: Cavallé-Busquets P; Inglès-Puig M; Fernandez-Ballart JD; Haro-Barceló J; Rojas-Gómez A; Ramos-Rodriguez C; Ballesteros M; Meyer K; Ueland PM; Murphy M (2020). Moderately elevated first trimester fasting plasma total homocysteine is associated with increased probability of miscarriage. The Reus-Tarragona Birth Cohort Study. Biochimie, 173(), 62-67. DOI: 10.1016/j.biochi.2020.01.008
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Acrónimo: MFP-COFUND
Tipo de publicación: Journal Publications
Autor según el artículo: Cavallé-Busquets P; Inglès-Puig M; Fernandez-Ballart JD; Haro-Barceló J; Rojas-Gómez A; Ramos-Rodriguez C; Ballesteros M; Meyer K; Ueland PM; Murphy MM
Departamento: Ciències Mèdiques Bàsiques Medicina i Cirurgia
Autor/es de la URV: Ballesteros Pérez, Monica / Cavallé Busquets, Pere / Fernández Ballart, Joan Domènech / Haro Barceló, Júlia / Murphy, Michelle / Ramos Rodríguez, Carla / Rojas Gómez, Alejandra
Resumen: © 2020 The association between elevated early pregnancy fasting plasma total homocysteine (tHcy) and miscarriage risk was investigated prospectively in participants (n = 544) from the Reus-Tarragona Birth Cohort study. Pregnancy was confirmed before 12 gestational weeks (GW) by ultrasound scan and a fasting blood sample collected. Pregnancies with complications other than miscarriages were excluded. Miscarriages were diagnosed by ultrasound scan and gestational age at the time of miscarriage estimated by embryo size, where possible. Cases in which blood samples were collected more than a week after the miscarriage, or the miscarriage was of known cause, were excluded. Fasting plasma folate, vitamin B12, tHcy, cotinine (biomarker of smoking), red blood cell (RBC) folate, MTHFR 677C > T (rs1801133) and SLC19A1 80G>A (rs1051266) genotypes were determined. The exposed group consisted of participants with first trimester tHcy ≥ P90 (7.1 μmol/L) (n = 57) and unexposed of those with tHcy < P90 (n = 487). Adherence to folic acid supplement recommendations, plasma folate, plasma vitamin B12, RBC folate and prevalence of optimal RBC folate status (≥ 906 μmol/L) were lower in the exposed compared to unexposed group. The prevalences of the MTHFR 677 TT genotype and miscarriage were higher in the exposed group. The relative risks (95% CI) of pregnancy ending in miscarriage were 2.5 (1.1, 5.7) and 2.1 (1.0, 4.5) for participants in the high tHcy and suboptimal RBC folate groups (compared to the reference groups) respectively. Adherence to folic acid supplement recommendations was positively associated, while the MTHFR 677 TT versus CC genotype and smoking versus non-smoking were negatively associated, with RBC folate status.
Áreas temáticas: Zootecnia / recursos pesqueiros Química Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Engenharias iv Engenharias ii Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 03009084
Direcció de correo del autor: monica.ballesteros@urv.cat carla.ramos@urv.cat pere.cavalleb@urv.cat michelle.murphy@urv.cat carla.ramos@urv.cat alejandra.rojas@urv.cat alejandra.rojas@urv.cat alejandra.rojas@urv.cat
Identificador del autor: 0000-0002-6304-6204 0000-0003-4427-2852 0000-0003-4427-2852 0000-0003-4427-2852
Fecha de publicacion del artículo: 18 january 2020
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0300908420300109?via%3Dihub
Programa de financiación: European Union Horizon 2020
DOI del artículo: 10.1016/j.biochi.2020.01.008
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Acción del progama de financiación: Marie Skłodowska-Curie