Author, as appears in the article.: Sandoval-Denis M; Gené J; Sutton D; Wiederhold N; Guarro J

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Gené Díaz, Josepa / Guarro Artigas, Josep / SANDOVAL DENIS, MARCELO PATRICIO

Keywords: Ribosomal dna Genus Fusispora brain-abscess

Abstract: Copyright © 2015, American Society for Microbiology. All Rights Reserved. Acrophialophora fusispora is an emerging opportunistic fungus capable of causing human infections. The taxonomy of the genus is not yet resolved and, in order to facilitate identification of clinical specimens, we have studied a set of clinical and environmental Acrophialophora isolates by morphological and molecular analyses. This set included the available type strains of Acrophialophora species and similar fungi, some of which were considered by various authors to be synonyms of A. fusispora. Sequence analysis of the large subunit (LSU) and internal transcribed spacer (ITS) regions of the nuclear ribosomal DNA and a fragment of the =-tubulin (Tub) gene revealed that Acrophialophora belongs in the family Chaetomiaceae and comprises three different species, i.e., A. fusispora, Acrophialophora levis, and Acrophialophora seudatica; the latter was previously included in the genus Ampullifera. The most prevalent species among clinical isolates was A. levis (72.7%), followed by A. fusispora (27.3%), both of which were isolated mostly from respiratory specimens (72.7%), as well as subcutaneous and corneal tissue samples. In general, of the eight antifungal drugs tested, voriconazole had the greatest in vitro activity, while all other agents showed poor in vitro activity against these fungi.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Microbiology (medical) Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Ensino Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Ciência da computação Biotecnología Biodiversidade

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00951137

Author's mail: josep.guarro@urv.cat josepa.gene@urv.cat

Author identifier: 0000-0002-7839-7568 0000-0001-6195-9299

Record's date: 2023-02-26

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://journals.asm.org/doi/full/10.1128/JCM.00279-15

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Clinical Microbiology. 53 (5): 1549-1555

APA: Sandoval-Denis M; Gené J; Sutton D; Wiederhold N; Guarro J (2015). Acrophialophora, a poorly known fungus with clinical significance. Journal Of Clinical Microbiology, 53(5), 1549-1555. DOI: 10.1128/JCM.00279-15

Article's DOI: 10.1128/JCM.00279-15

Entity: Universitat Rovira i Virgili

Journal publication year: 2015

Publication Type: Journal Publications