Autor según el artículo: Sandoval-Denis M; Gené J; Sutton D; Wiederhold N; Guarro J

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Gené Díaz, Josepa / Guarro Artigas, Josep / SANDOVAL DENIS, MARCELO PATRICIO

Palabras clave: Ribosomal dna Genus Fusispora brain-abscess

Resumen: Copyright © 2015, American Society for Microbiology. All Rights Reserved. Acrophialophora fusispora is an emerging opportunistic fungus capable of causing human infections. The taxonomy of the genus is not yet resolved and, in order to facilitate identification of clinical specimens, we have studied a set of clinical and environmental Acrophialophora isolates by morphological and molecular analyses. This set included the available type strains of Acrophialophora species and similar fungi, some of which were considered by various authors to be synonyms of A. fusispora. Sequence analysis of the large subunit (LSU) and internal transcribed spacer (ITS) regions of the nuclear ribosomal DNA and a fragment of the =-tubulin (Tub) gene revealed that Acrophialophora belongs in the family Chaetomiaceae and comprises three different species, i.e., A. fusispora, Acrophialophora levis, and Acrophialophora seudatica; the latter was previously included in the genus Ampullifera. The most prevalent species among clinical isolates was A. levis (72.7%), followed by A. fusispora (27.3%), both of which were isolated mostly from respiratory specimens (72.7%), as well as subcutaneous and corneal tissue samples. In general, of the eight antifungal drugs tested, voriconazole had the greatest in vitro activity, while all other agents showed poor in vitro activity against these fungi.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Microbiology (medical) Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Ensino Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Ciência da computação Biotecnología Biodiversidade

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00951137

Direcció de correo del autor: josep.guarro@urv.cat josepa.gene@urv.cat

Identificador del autor: 0000-0002-7839-7568 0000-0001-6195-9299

Fecha de alta del registro: 2023-02-26

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://journals.asm.org/doi/full/10.1128/JCM.00279-15

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Journal Of Clinical Microbiology. 53 (5): 1549-1555

Referencia de l'ítem segons les normes APA: Sandoval-Denis M; Gené J; Sutton D; Wiederhold N; Guarro J (2015). Acrophialophora, a poorly known fungus with clinical significance. Journal Of Clinical Microbiology, 53(5), 1549-1555. DOI: 10.1128/JCM.00279-15

DOI del artículo: 10.1128/JCM.00279-15

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2015

Tipo de publicación: Journal Publications