Articles producció científica> Bioquímica i Biotecnologia

Grape-seed proanthocyanidin extract reverts obesity-related metabolic derangements in aged female rats

  • Identification data

    Identifier: imarina:9218792
    Authors:
    Sierra-Cruz, MartaMiguens-Gomez, AlbaGrau-Bove, CarmeRodriguez-Gallego, EstherBlay, MaytePinent, MontserratArdevol, AnnaTerra, XimenaBeltran-Debon, Raul
    Abstract:
    Obesity and ageing are current issues of global concern. Adaptive homeostasis is compromised in the elderly, who are more likely to suffer age-related health issues, such as obesity, metabolic syndrome, and cardiovascular disease. The current worldwide prevalence of obesity and higher life expectancy call for new strategies for treating metabolic disorders. Grape-seed proanthocyanidin extract (GSPE) is reported to be effective in ameliorating these pathologies, especially in young animal models. In this study, we aimed to test the effectiveness of GSPE in modulating obesity-related pathologies in aged rats fed an obesogenic diet. To do so, 21-month-old rats were fed a high-fat/high-sucrose diet (cafeteria diet) for 11 weeks. Two time points for GSPE administration (500 mg/kg body weight), i.e., a 10-day preventive GSPE treatment prior to cafeteria diet intervention and a simultaneous GSPE treatment with the cafeteria diet, were assayed. Body weight, metabolic parameters, liver steatosis, and systemic inflammation were analysed. GSPE administered simultaneously with the cafeteria diet was effective in reducing body weight, total adiposity, and liver steatosis. However, the preventive treatment was effective in reducing only mesenteric adiposity in these obese, aged rats. Our results confirm that the simultaneous administration of GSPE improves metabolic disruptions caused by the cafeteria diet also in aged rats.
  • Others:

    Author, as appears in the article.: Sierra-Cruz, Marta; Miguens-Gomez, Alba; Grau-Bove, Carme; Rodriguez-Gallego, Esther; Blay, Mayte; Pinent, Montserrat; Ardevol, Anna; Terra, Ximena; Beltran-Debon, Raul
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Sierra Cruz, Marta / Terra Barbadora, Ximena
    Keywords: Weight loss Rats, wistar Rats Proanthocyanidins Obesity Metabolic syndrome Liver steatosis Insulin Grape seed proanthocyanidins Grape seed extract Glucagon Female Fatty liver Disease models, animal Diet-induced obesity Blood glucose Animals Ageing Adiposity resveratrol proanthocyanidins model metabolic syndrome liver steatosis liver intestinal inflammation insulin-resistance high-fat diet gut microbiota cafeteria diet body-weight ageing adiposity
    Abstract: Obesity and ageing are current issues of global concern. Adaptive homeostasis is compromised in the elderly, who are more likely to suffer age-related health issues, such as obesity, metabolic syndrome, and cardiovascular disease. The current worldwide prevalence of obesity and higher life expectancy call for new strategies for treating metabolic disorders. Grape-seed proanthocyanidin extract (GSPE) is reported to be effective in ameliorating these pathologies, especially in young animal models. In this study, we aimed to test the effectiveness of GSPE in modulating obesity-related pathologies in aged rats fed an obesogenic diet. To do so, 21-month-old rats were fed a high-fat/high-sucrose diet (cafeteria diet) for 11 weeks. Two time points for GSPE administration (500 mg/kg body weight), i.e., a 10-day preventive GSPE treatment prior to cafeteria diet intervention and a simultaneous GSPE treatment with the cafeteria diet, were assayed. Body weight, metabolic parameters, liver steatosis, and systemic inflammation were analysed. GSPE administered simultaneously with the cafeteria diet was effective in reducing body weight, total adiposity, and liver steatosis. However, the preventive treatment was effective in reducing only mesenteric adiposity in these obese, aged rats. Our results confirm that the simultaneous administration of GSPE improves metabolic disruptions caused by the cafeteria diet also in aged rats.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: alba.miguens@urv.cat alba.miguens@urv.cat alba.miguens@urv.cat marta.sierra@estudiants.urv.cat marta.sierra@estudiants.urv.cat anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
    Author identifier: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
    Record's date: 2024-10-19
    Journal volume: 13
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/13/6/2059
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 13 (6): 2059-
    APA: Sierra-Cruz, Marta; Miguens-Gomez, Alba; Grau-Bove, Carme; Rodriguez-Gallego, Esther; Blay, Mayte; Pinent, Montserrat; Ardevol, Anna; Terra, Ximena; B (2021). Grape-seed proanthocyanidin extract reverts obesity-related metabolic derangements in aged female rats. Nutrients, 13(6), 2059-. DOI: 10.3390/nu13062059
    Article's DOI: 10.3390/nu13062059
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Weight loss
    Rats, wistar
    Rats
    Proanthocyanidins
    Obesity
    Metabolic syndrome
    Liver steatosis
    Insulin
    Grape seed proanthocyanidins
    Grape seed extract
    Glucagon
    Female
    Fatty liver
    Disease models, animal
    Diet-induced obesity
    Blood glucose
    Animals
    Ageing
    Adiposity
    resveratrol
    proanthocyanidins
    model
    metabolic syndrome
    liver steatosis
    liver
    intestinal inflammation
    insulin-resistance
    high-fat diet
    gut microbiota
    cafeteria diet
    body-weight
    ageing
    adiposity
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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