Author, as appears in the article.: Sierra-Cruz M; Miguéns-Gómez A; Grau-Bové C; Rodríguez-Gallego E; Blay M; Pinent M; Ardévol A; Terra X; Beltrán-Debón R

Department: Bioquímica i Biotecnologia

URV's Author/s: Ardèvol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Pinent Armengol, Montserrat / Terra Barbadora, Ximena

Keywords: Proanthocyanidins Obesity Metabolic syndrome Liver steatosis Diet-induced obesity Ageing Adiposity resveratrol proanthocyanidins model metabolic syndrome liver steatosis liver intestinal inflammation insulin-resistance high-fat diet gut microbiota cafeteria diet body-weight ageing adiposity

Abstract: Obesity and ageing are current issues of global concern. Adaptive homeostasis is compromised in the elderly, who are more likely to suffer age-related health issues, such as obesity, metabolic syndrome, and cardiovascular disease. The current worldwide prevalence of obesity and higher life expectancy call for new strategies for treating metabolic disorders. Grape-seed proanthocyanidin extract (GSPE) is reported to be effective in ameliorating these pathologies, especially in young animal models. In this study, we aimed to test the effectiveness of GSPE in modulating obesity-related pathologies in aged rats fed an obesogenic diet. To do so, 21-month-old rats were fed a high-fat/high-sucrose diet (cafeteria diet) for 11 weeks. Two time points for GSPE administration (500 mg/kg body weight), i.e., a 10-day preventive GSPE treatment prior to cafeteria diet intervention and a simultaneous GSPE treatment with the cafeteria diet, were assayed. Body weight, metabolic parameters, liver steatosis, and systemic inflammation were analysed. GSPE administered simultaneously with the cafeteria diet was effective in reducing body weight, total adiposity, and liver steatosis. However, the preventive treatment was effective in reducing only mesenteric adiposity in these obese, aged rats. Our results confirm that the simultaneous administration of GSPE improves metabolic disruptions caused by the cafeteria diet also in aged rats.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: ximena.terra@urv.cat raul.beltran@urv.cat montserrat.pinent@urv.cat mteresa.blay@urv.cat anna.ardevol@urv.cat

Author identifier: 0000-0003-1043-5844 0000-0001-9691-1906 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-0156-7538

Record's date: 2023-03-05

Journal volume: 13

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/13/6/2059

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 13 (6):

APA: Sierra-Cruz M; Miguéns-Gómez A; Grau-Bové C; Rodríguez-Gallego E; Blay M; Pinent M; Ardévol A; Terra X; Beltrán-Debón R (2021). Grape-seed proanthocyanidin extract reverts obesity-related metabolic derangements in aged female rats. Nutrients, 13(6), -. DOI: 10.3390/nu13062059

Article's DOI: 10.3390/nu13062059

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications