Author, as appears in the article.: Navarro-Masip, E; Manocchio, F; Rodriguez, RM; Bravo, FI; Torres-Fuentes, C; Muguerza, B; Aragones, G
Department: Bioquímica i Biotecnologia
URV's Author/s: Aragonès Bargalló, Gerard / Bravo Vázquez, Francisca Isabel / Manocchio, Francesca / Muguerza Marquínez, Maria Begoña / Navarro Masip, Èlia / RODRÍGUEZ SÁNCHEZ, ROSA MARIA / Torres Fuentes, Cristina
Keywords: Lipolysis Lipid-metabolism Corticosterone Biological rhythms Adiponectin (poly)phenols white mass lipolysis leptin glycerol food-intake extract density corticosterone biological rhythms adiponectin (poly)phenols
Abstract: Variations in photoperiod patterns drive metabolic adaptations in mammals, involving important changes in body weight and adiposity. Moreover, (poly)phenols can help heterotrophs adopt metabolic adaptations to face the upcoming environmental conditions. Particularly, proanthocyanidins from grape-seeds show photoperiod-dependent effects on different metabolic parameters. The present study aims to explore whether grape-seed proanthocyanidin extract (GSPE) consumption differently affects the expression of metabolic markers in WAT (subcutaneous and visceral depots) and BAT in a photoperiod-dependent manner.GSPE (25 mg kg-1 day-1 ) is orally administrated for 4 weeks to healthy rats exposed to three photoperiods (L6, L12, and L18). In WAT, GSPE consumption significantly upregulates the expression of lipolytic genes in all photoperiods, being accompanied by increased serum concentrations of glycerol and corticosterone only under the L6 photoperiod. Moreover, adiponectin mRNA levels are significantly upregulated in response to GSPE regardless of the photoperiod, whereas Tnfα and Il6 expression are only downregulated in L6 and L18 photoperiods but not in L12. In BAT, GSPE upregulates Pgc1α expression in all groups, whereas the expression of Pparα is only increased in L18.The results indicate that GSPE modulates the expression of important metabolic markers of WAT and BAT in a photoperiod-dependent manner.© 2023 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH.
Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: francesca.manocchio@urv.cat francesca.manocchio@urv.cat francesca.manocchio@urv.cat elia.navarro@estudiants.urv.cat elia.navarro@estudiants.urv.cat franciscaisabel.bravo@urv.cat gerard.aragones@urv.cat begona.muguerza@urv.cat cristina.torres@urv.cat
Author identifier: 0000-0002-6468-3088 0000-0001-7384-8588 0000-0002-2917-6910
Record's date: 2024-09-21
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202300035
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Nutrition & Food Research. 67 (17): e2300035-e2300035
APA: Navarro-Masip, E; Manocchio, F; Rodriguez, RM; Bravo, FI; Torres-Fuentes, C; Muguerza, B; Aragones, G (2023). Photoperiod-Dependent Effects of Grape-Seed Proanthocyanidins on Adipose Tissue Metabolic Markers in Healthy Rats. Molecular Nutrition & Food Research, 67(17), e2300035-e2300035. DOI: 10.1002/mnfr.202300035
Article's DOI: 10.1002/mnfr.202300035
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV