Articles producció científica> Bioquímica i Biotecnologia

Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk

  • Identification data

    Identifier: imarina:9366387
    Authors:
    Alam, Aniqa BToledo-Atucha, EstefaniaRomaguera, DoraAlonso-Gomez, Angel MMartinez-Gonzalez, Miguel ATojal-Sierra, LucasMora, Marta NorisMas-Llado, CaterinaLi, LinziGonzalez-Casanova, InesSalas-Salvado, JordiFito, MontserratAlonso, Alvaro
    Abstract:
    Background Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.Methods and Results We studied 503 participants from the PREDIMED-Plus (Prevencion con Dieta Mediterranea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]).Conclusions In a population at high cardiovascular risk, increased alcohol consumption
  • Others:

    Author, as appears in the article.: Alam, Aniqa B; Toledo-Atucha, Estefania; Romaguera, Dora; Alonso-Gomez, Angel M; Martinez-Gonzalez, Miguel A; Tojal-Sierra, Lucas; Mora, Marta Noris; Mas-Llado, Caterina; Li, Linzi; Gonzalez-Casanova, Ines; Salas-Salvado, Jordi; Fito, Montserrat; Alonso, Alvaro
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Salas Salvadó, Jorge
    Keywords: Volume Validity Stroke Speckle-tracking echocardiography Heart Fibrillation Countries Atrial structure and function Atrial fibrillation Alcohol consumption
    Abstract: Background Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.Methods and Results We studied 503 participants from the PREDIMED-Plus (Prevencion con Dieta Mediterranea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]).Conclusions In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargement and worsening atrial function.Registration URL: http://www.controlled-trials.com; Unique identifier: ISRCTN89898870.
    Thematic Areas: Saúde coletiva Nutrição Medicina ii Medicina i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.salas@urv.cat
    Author identifier: 0000-0003-2700-7459
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.ahajournals.org/doi/10.1161/JAHA.123.031915
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of The American Heart Association. 13 (7): e031915-
    APA: Alam, Aniqa B; Toledo-Atucha, Estefania; Romaguera, Dora; Alonso-Gomez, Angel M; Martinez-Gonzalez, Miguel A; Tojal-Sierra, Lucas; Mora, Marta Noris; (2024). Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk. Journal Of The American Heart Association, 13(7), e031915-. DOI: 10.1161/JAHA.123.031915
    Article's DOI: 10.1161/JAHA.123.031915
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine
    Volume
    Validity
    Stroke
    Speckle-tracking echocardiography
    Heart
    Fibrillation
    Countries
    Atrial structure and function
    Atrial fibrillation
    Alcohol consumption
    Saúde coletiva
    Nutrição
    Medicina ii
    Medicina i
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología
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