Autor según el artículo: Paredes K; Capilla J; Mayayo E; Guarro J

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Capilla Luque, Javier / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel / Paredes Aguilar, Katihuska Viviana

Resumen: Scopulariopsis is an emerging opportunistic fungus characterized by its high resistance to antifungal therapies. We have developed a murine model of disseminated infection in immunosuppressed animals by intravenous inoculation of Scopulariopsis brevicaulis and Scopulariopsis brumptii, the most clinically relevant species, in order to evaluate their virulence and their responses to conventional antifungal treatments. Survival and tissue burden studies showed that S. brumptii was more virulent than S. brevicaulis. The three drugs tested, liposomal amphotericin B, posaconazole, and voriconazole, prolonged the survival of mice infected with S. brumptii, but none showed efficacy against S. brevicaulis. The different therapies were only able to modestly reduce the fungal burden of infected tissue; however, in general, despite the high serum levels reached, they showed poor efficacy in the treatment of the infection. Unfortunately, the most effective therapy for Scopulariopsis infections remains unresolved.

Áreas temáticas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00664804

Direcció de correo del autor: kathiuska.paredes@urv.cat josep.guarro@urv.cat emilio.mayayo@urv.cat javier.capilla@urv.cat

Identificador del autor: 0000-0001-9078-3800 0000-0002-7839-7568 0000-0003-4485-3809 0000-0002-0765-6403

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://aac.asm.org/content/60/4/2063

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Antimicrobial Agents And Chemotherapy. 60 (4): 2063-2068

Referencia de l'ítem segons les normes APA: Paredes K; Capilla J; Mayayo E; Guarro J (2016). Virulence and resistance to antifungal therapies of Scopulariopsis species. Antimicrobial Agents And Chemotherapy, 60(4), 2063-2068. DOI: 10.1128/AAC.02275-15

DOI del artículo: 10.1128/AAC.02275-15

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Tipo de publicación: Journal Publications