Autor según el artículo: Celia Sequera; Ana Vázquez Carballo; María Arechederra; Sonia Fernández Veledo; Almudena Porras.
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Fernandez Veledo, Sonia
Palabras clave: Weak inducer Tweak Tnf-alpha Superfamily member Nf-kappa-b Multifunctional cytokine Migration Kinase Glioma-cell invasion Fibulin 3 Fibrosis Expression Erks Apoptosis tweak tweak fibulin 3 erks
Resumen: TWEAK regulates multiple physio-pathological processes in fibroblasts such as fibrosis. It also induces migration and invasion in tumors and it can activate p38 MAPK in various cell types. Moreover, p38? MAPK promotes migration and invasion in several cancer cells types and in mouse embryonic fibroblasts (MEFs). However, it remains unknown if TWEAK could promote migration in fibroblasts and whether p38? MAPK might play a role. Our results reveal that TWEAK activates ERKs, Akt, and p38?/? MAPKs and reduces secreted Fibulin 3 in MEFs. TWEAK also increases migration and invasion in wt and p38? deficient MEFs, which indicates that p38? MAPK is not required to mediate these effects. In contrast, ERKs inhibition significantly decreases TWEAK-induced migration and Fibulin 3 knock-down mimics TWEAK effect. These results indicate that both ERKs activation and Fibulin 3 down-regulation would contribute to mediate TWEAK pro-migratory effect. In fact, the additional regulation of ERKs and/or p38? as a consequence of Fibulin 3 decrease might be also involved in the pro-migratory effect of TWEAK in MEFs. In conclusion, our studies uncover novel mechanisms by which TWEAK would favor tissue repair by promoting fibroblasts migration.© 2017 Wiley Periodicals, Inc.
Áreas temáticas: Química Physiology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Enfermagem Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cell biology Biotecnología Biodiversidade
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00219541
Direcció de correo del autor: sonia.fernandez@urv.cat
Identificador del autor: 0000-0003-2906-3788
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.25942
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Journal Of Cellular Physiology. 233 (2): 968-978
Referencia de l'ítem segons les normes APA: Celia Sequera; Ana Vázquez Carballo; María Arechederra; Sonia Fernández Veledo; Almudena Porras. (2018). TWEAK promotes migration and invasion in MEFs through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation.. Journal Of Cellular Physiology, 233(2), 968-978. DOI: 10.1002/jcp.25942
DOI del artículo: 10.1002/jcp.25942
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2018
Tipo de publicación: Journal Publications
Repositori URV