Autor según el artículo: Hernáez Á; Soria-Florido MT; Schröder H; Ros E; Pintó X; Estruch R; Salas-Salvadó J; Corella D; Arós F; Serra-Majem L; Martínez-González MÁ; Fiol M; Lapetra J; Elosua R; Lamuela-Raventós RM; Fitó M
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Salas Salvadó, Jorge
Palabras clave: Adult Age Age factors Aged Article Atherosclerosis Blood Body mass Cardiovascular disease Cardiovascular diseases Cardiovascular risk Cholesterol Cholesterol, hdl Cholesterol, ldl Complication Controlled study Cross-sectional studies Cross-sectional study Diabetes mellitus Diabetes mellitus, type 2 Disease association Dyslipidemia Dyslipidemias Female Framingham risk score High density lipoprotein High density lipoprotein cholesterol Human Humans Hypertension Lipoproteins, hdl Lipoproteins, ldl Low density lipoprotein Low density lipoprotein cholesterol Major clinical study Male Middle aged Non insulin dependent diabetes mellitus Obesity Oxidation Prediction Protein function Risk factor Risk factors Sex Sex factor Sex factors Smoking habit
Resumen: BACKGROUND: High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors. OBJECTIVE: To determine which lipoprotein properties are associated with greater cardiovascular risk scores and each cardiovascular risk factor. METHODS: In two cross-sectional baseline samples of PREDIMED trial volunteers, we assessed the associations of HDL functionality (N = 296) and LDL atherogenicity traits (N = 210) with: 1) the 10-year predicted coronary risk (according to the Framingham-REGICOR score), and 2) classical cardiovascular risk factors. RESULTS: Greater cardiovascular risk scores were associated with low cholesterol efflux values; oxidized, triglyceride-rich, small HDL particles; and small LDLs with low resistance against oxidation (P-trend<0.05, all). After adjusting for the rest of risk factors; 1) type-2 diabetic individuals presented smaller and more oxidized LDLs (P<0.026, all); 2) dyslipidemic participants had smaller HDLs with an impaired capacity to metabolize cholesterol (P<0.035, all); 3) high body mass index values were associated to lower HDL and LDL size and a lower HDL capacity to esterify cholesterol (P<0.037, all); 4) men presented a greater HDL oxidation and lower HDL vasodilatory capacity (P<0.046, all); and 5) greater ages were related to small, oxidized, cytotoxic LDL particles (P<0.037, all). CONCLUSIONS: Dysfunctional HDL and atherogenic LDL particles are present in high cardiovascular risk patients. Dyslipidemia and male sex are predominantly linked to HDL dysfunctionality, whilst diabetes and advanced age are associated with LDL atherogenicity.
Áreas temáticas: Administração pública e de empresas, ciências contábeis e turismo Administração, ciências contábeis e turismo Agricultural and biological sciences (miscellaneous) Anthropology Antropologia / arqueologia Archaeology Arquitetura, urbanismo e design Astronomia / física Biochemistry, genetics and molecular biology (miscellaneous) Biodiversidade Biology Biotecnología Ciência da computação Ciência de alimentos Ciência política e relações internacionais Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Ciências sociais aplicadas i Comunicação e informação Demography Direito Economia Educação Educação física Enfermagem Engenharias i Engenharias ii Engenharias iii Engenharias iv Ensino Environmental studies Farmacia General agricultural and biological sciences General biochemistry,genetics and molecular biology General medicine Geociências Geografía Historia History & philosophy of science Human geography and urban studies Interdisciplinar Interdisciplinary research in the social sciences Letras / linguística Linguística e literatura Matemática / probabilidade e estatística Materiais Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Multidisciplinary Multidisciplinary sciences Nutrição Odontología Planejamento urbano e regional / demografia Psicología Psychology Química Saúde coletiva Serviço social Sociología Sociology Zootecnia / recursos pesqueiros
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: jordi.salas@urv.cat
ISSN: 19326203
Identificador del autor: 0000-0003-2700-7459
Fecha de alta del registro: 2023-02-18
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218533
Referencia al articulo segun fuente origial: Plos One. 14 (6): e0218533-
Referencia de l'ítem segons les normes APA: Hernáez Á; Soria-Florido MT; Schröder H; Ros E; Pintó X; Estruch R; Salas-Salvadó J; Corella D; Arós F; Serra-Majem L; Martínez-González MÁ; Fiol M; L (2019). Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination. Plos One, 14(6), e0218533-. DOI: 10.1371/journal.pone.0218533
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1371/journal.pone.0218533
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Tipo de publicación: Journal Publications
Repositori URV