Articles producció científica> Enginyeria Química

Ciprofloxacin and graphene oxide combination-New face of a known drug

  • Datos identificativos

    Identificador: imarina:9002811
    Autores:
    Matulewicz KKaźmierski ŁWiśniewski MRoszkowski SRoszkowski KKowalczyk ORoy ATylkowski BBajek A
    Resumen:
    © 2020 by the authors. Drug modification with nanomaterials is a new trend in pharmaceutical studies and shows promising results, especially considering carbon-based solutions. Graphene and its derivatives have attracted much research interest for their potential applications in biomedical areas as drug modifiers. The following work is a comprehensive study regarding the toxicity of ciprofloxacin (CIP) modified by graphene oxide (GO). The influence on the morphology, viability, cell death pathway and proliferation of T24 and 786-0 cells was studied. The results show that ciprofloxacin modified with graphene oxide (CGO) shows the highest increase in cytotoxic potential, especially in the case of T24 cells. We discovered a clear connection between CIP modification with GO and the increase in its apoptotic potential. Our results show that drug modification with carbon-based nanomaterials might be a promising strategy to improve the qualities of existing drugs. Nevertheless, it is important to remember that cytotoxicity effects are highly dependent on dose and nanomaterial size. It is necessary to conduct further research to determine the optimal dose of GO for drug modification.
  • Otros:

    Autor según el artículo: Matulewicz K; Kaźmierski Ł; Wiśniewski M; Roszkowski S; Roszkowski K; Kowalczyk O; Roy A; Tylkowski B; Bajek A
    Departamento: Enginyeria Química
    Autor/es de la URV: Tylkowski, Bartosz
    Palabras clave: Size Nanosheets In-vitro Graphene oxide Drug modification Delivery Carrier Carbon-based materials Anticancer drug Accumulation
    Resumen: © 2020 by the authors. Drug modification with nanomaterials is a new trend in pharmaceutical studies and shows promising results, especially considering carbon-based solutions. Graphene and its derivatives have attracted much research interest for their potential applications in biomedical areas as drug modifiers. The following work is a comprehensive study regarding the toxicity of ciprofloxacin (CIP) modified by graphene oxide (GO). The influence on the morphology, viability, cell death pathway and proliferation of T24 and 786-0 cells was studied. The results show that ciprofloxacin modified with graphene oxide (CGO) shows the highest increase in cytotoxic potential, especially in the case of T24 cells. We discovered a clear connection between CIP modification with GO and the increase in its apoptotic potential. Our results show that drug modification with carbon-based nanomaterials might be a promising strategy to improve the qualities of existing drugs. Nevertheless, it is important to remember that cytotoxicity effects are highly dependent on dose and nanomaterial size. It is necessary to conduct further research to determine the optimal dose of GO for drug modification.
    Áreas temáticas: Physics, condensed matter Physics, applied Metallurgy & metallurgical engineering Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) Condensed matter physics Chemistry, physical
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: bartosz.tylkowski@urv.cat
    Identificador del autor: 0000-0002-4163-0178
    Fecha de alta del registro: 2023-02-19
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/1996-1944/13/19/4224
    Referencia al articulo segun fuente origial: Materials. 13 (19):
    Referencia de l'ítem segons les normes APA: Matulewicz K; Kaźmierski Ł; Wiśniewski M; Roszkowski S; Roszkowski K; Kowalczyk O; Roy A; Tylkowski B; Bajek A (2020). Ciprofloxacin and graphene oxide combination-New face of a known drug. Materials, 13(19), -. DOI: 10.3390/MA13194224
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.3390/MA13194224
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Chemistry, Physical,Condensed Matter Physics,Materials Science (Miscellaneous),Materials Science, Multidisciplinary,Metallurgy & Metallurgical Engineering,Physics, Applied,Physics, Condensed Matter
    Size
    Nanosheets
    In-vitro
    Graphene oxide
    Drug modification
    Delivery
    Carrier
    Carbon-based materials
    Anticancer drug
    Accumulation
    Physics, condensed matter
    Physics, applied
    Metallurgy & metallurgical engineering
    Materials science, multidisciplinary
    Materials science (miscellaneous)
    Materials science (all)
    Condensed matter physics
    Chemistry, physical
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