Articles producció científica> Bioquímica i Biotecnologia

Large gene overlaps in prokaryotic genomes: result of functional constraints or mispredictions?

  • Datos identificativos

    Identificador: imarina:9048004
    Handle: https://hdl.handle.net/20.500.11797/imarina9048004
    Autores:
    Resumen:
    Across the fully sequenced microbial genomes there are thousands of examples of overlapping genes. Many of these are only a few nucleotides long and are thought to function by permitting the coordinated regulation of gene expression. However, there should also be selective pressure against long overlaps, as the existence of overlapping reading frames increases the risk of deleterious mutations. Here we examine the longest overlaps and assess whether they are the product of special functional constraints or of erroneous annotation.

  • Otros:

    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-9-335
    Departamento: Bioquímica i Biotecnologia
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Autor/es de la URV: Pallejà, Albert; D Harrington, Eoghan; Bork, Peer
    DOI del artículo: 10.1186/1471-2164-9-335
    Resumen: Across the fully sequenced microbial genomes there are thousands of examples of overlapping genes. Many of these are only a few nucleotides long and are thought to function by permitting the coordinated regulation of gene expression. However, there should also be selective pressure against long overlaps, as the existence of overlapping reading frames increases the risk of deleterious mutations. Here we examine the longest overlaps and assess whether they are the product of special functional constraints or of erroneous annotation.
    Año de publicación de la revista: 2008
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Fecha de alta del registro: 2021-02-05
    Volumen de revista: 9