Articles producció científica> Enginyeria Química

Framework for risk assessment of PFAS utilizing experimental studies and in-silico models

  • Datos identificativos

    Identificador: imarina:9243005
    Handle: http://hdl.handle.net/20.500.11797/imarina9243005
  • Autores:

    Deepika D
    Rovira J
    Sabuz Ó
    Balaguer J
    Schuhmacher M
    Domingo JL
    Kumar V
  • Otros:

    Autor según el artículo: Deepika D; Rovira J; Sabuz Ó; Balaguer J; Schuhmacher M; Domingo JL; Kumar V
    Departamento: Enginyeria Química
    Autor/es de la URV: Balaguer Trias, Jordina / Domingo Roig, José Luis / Kumar, Vikas / Rovira Solano, Joaquim / Schuhmacher Ansuategui, Marta
    Palabras clave: Translational in silico models Toxicokinetic model Systematic analysis Regulatory limits Pfos Pfoa Pfas Perfluorinated compounds Human biomonitoring Health effects Dietary toxicity translational in silico models toxicokinetic model systematic analysis substances regulatory limits pfos pfoa pfas perfluorooctanesulfonate life human biomonitoring health effects exposure
    Resumen: Perfluoroalkyl substances (PFAS), especially PFOS and PFOA, are two widely used synthetic chemicals that can impact human health based on evidence from animal and epidemiologic studies. In this paper, we have reviewed and summarized the influence of PFAS exposure on health, pointing the quality of evidence, and applied translational techniques to integrate evidence for PFAS policy making. This is the first review where highly referred articles on PFAS used for policymaking by several regulatory agencies were collected and evaluated based on the review guidelines developed by the US National Toxicology Program's Office of Health Assessment and Translation (OHAT) review guidelines. Several limitations were observed, including co-exposure to multiple chemicals and limited measurement of primary and secondary outcomes related to specific toxicity. However, data from all the studies provided a moderate to strong level of confidence for link between PFAS exposure and different adverse outcomes. Secondly, for translating the risk to humans, an in-silico model and scaling approach was utilized. Physiologically based pharmacokinetic model (PBPK) was used to calculate the human equivalent dose (HED) from two widely accepted studies and compared with tolerable daily intakes (TDIs) established by various regulatory agencies. Inter-species dose extrapolation was done to compare with human the relevance of dosing scenarios used in animals. Overall, a framework for translation of risk was proposed based on the conclusions of this review with the goal of improving policymaking. The current paper can improve the methodological protocols for PFAS experimental studies and encourage the utilization of in-silico models for translating risk.Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: joaquim.rovira@urv.cat vikas.kumar@urv.cat jordina.balaguer@urv.cat marta.schuhmacher@urv.cat joseluis.domingo@urv.cat jordina.balaguer@urv.cat
    Identificador del autor: 0000-0003-4399-6138 0000-0002-9795-5967 0000-0001-9001-207X 0000-0003-4381-2490 0000-0001-6647-9470 0000-0001-9001-207X
    Fecha de alta del registro: 2023-02-23
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0013935122000494?via%3Dihub
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Environmental Research. 208 112722-112722
    Referencia de l'ítem segons les normes APA: Deepika D; Rovira J; Sabuz Ó; Balaguer J; Schuhmacher M; Domingo JL; Kumar V (2022). Framework for risk assessment of PFAS utilizing experimental studies and in-silico models. Environmental Research, 208(), 112722-112722. DOI: 10.1016/j.envres.2022.112722
    DOI del artículo: 10.1016/j.envres.2022.112722
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry,Environmental Science (Miscellaneous),Environmental Sciences,Public, Environmental & Occupational Health
    Translational in silico models
    Toxicokinetic model
    Systematic analysis
    Regulatory limits
    Pfos
    Pfoa
    Pfas
    Perfluorinated compounds
    Human biomonitoring
    Health effects
    Dietary toxicity
    translational in silico models
    toxicokinetic model
    systematic analysis
    substances
    regulatory limits
    pfos
    pfoa
    pfas
    perfluorooctanesulfonate
    life
    human biomonitoring
    health effects
    exposure
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General medicine
    General environmental science
    Farmacia
    Environmental sciences
    Environmental science (miscellaneous)
    Environmental science (all)
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Direito
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Biochemistry
    Astronomia / física
  • Documentos:

  • Cerca a google

    Search to google scholar