Autor según el artículo: Jalsevac, Florijan; Terra, Ximena; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Maria Teresa; Pinent, Montserrat; Ardevol, Anna
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Jalsevac, Florijan / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena
Código de proyecto: Grant agreement No. 945413
Palabras clave: Taste buds Taste Tas2r39 antagonist Tas2r39 agonist Tas2r39 Respiratory system Receptors, g-protein-coupled Gpcr Gastrointestinal tract Food intake Catechin Bitter taste Animals
Resumen: Over thousands of years of evolution, animals have developed many ways to protect themselves. One of the most protective ways to avoid disease is to prevent the absorption of harmful components. This protective function is a basic role of bitter taste receptors (TAS2Rs), a G protein-coupled receptor family, whose presence in extraoral tissues has intrigued many researchers. In humans, there are 25 TAS2Rs, and although we know a great deal about some of them, others are still shrouded in mystery. One in this latter category is bitter taste receptor 39 (TAS2R39). Besides the oral cavity, it has also been found in the gastrointestinal tract and the respiratory, nervous and reproductive systems. TAS2R39 is a relatively non-selective receptor, which means that it can be activated by a range of mostly plant-derived compounds such as theaflavins, catechins and isoflavones. On the other hand, few antagonists for this receptor are available, since only some flavones have antagonistic properties (all of them detailed in the document). The primary role of TAS2R39 is to sense the bitter components of food and protect the organism from harmful compounds. There is also some indication that this bitter taste receptor regulates enterohormones and in turn, regulates food intake. In the respiratory system, it may be involved in the congestion process of allergic rhinitis and may stimulate inflammatory cytokines. However, more thorough research is needed to determine the precise role of TAS2R39 in these and other tissues.
Áreas temáticas: Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
Identificador del autor: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
Fecha de alta del registro: 2024-10-19
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fendo.2022.854718/full
Programa de financiación: Marie Sklodowska-Curie Actions – European Union’s Horizon 2020 research and innovation programme
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Frontiers In Endocrinology. 13 854718-
Referencia de l'ítem segons les normes APA: Jalsevac, Florijan; Terra, Ximena; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Blay, Maria Teresa; Pinent, Montserrat; Ardevol, Anna (2022). The Hidden One: What We Know About Bitter Taste Receptor 39. Frontiers In Endocrinology, 13(), 854718-. DOI: 10.3389/fendo.2022.854718
Acrónimo: MFP-Plus
DOI del artículo: 10.3389/fendo.2022.854718
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Acción del progama de financiación: Martí i Franquès COFUND Doctoral Programme
Tipo de publicación: Journal Publications