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Maternal factors associated with iron deficiency without anaemia in early pregnancy: ECLIPSES study

  • Datos identificativos

    Identificador: imarina:9291950
    Autores:
    Iglesias-Vázquez, LGimeno, MCoronel, PCaspersen, IHBasora, JArija, V
    Resumen:
    Several population-specific genetic, sociodemographic, and maternal lifestyle factors are related to iron status in early pregnancy, and their identification would allow preventive actions to be taken. The study aimed to identify maternal factors associated with iron deficiency (ID) in early pregnancy in non-anaemic pregnant women from a European Mediterranean country. Cross-sectional study using the initial population of the ECLIPSES study performed in non-anaemic pregnant women before gestational week 12. Serum ferritin (SF) and haemoglobin concentrations were measured to evaluate iron status, and ID was defined as SF < 15 µg/L. Several sociodemographic and lifestyle data were recorded and used as covariates in the multivariate-adjusted regression models. Out of the 791 participants, 13.9% had ID in early pregnancy. Underweight (OR 3.70, 95%CI 1.22, 15.53) and parity (1 child: OR 2.03, 95%CI 1.06, 3.88; ≥ 2 children: OR 6.96, 95%CI 3.09, 15.69) increased the odds of ID, while a high intake of total meat (≥ 108.57 g/day: OR 0.37, 95%CI 0.15, 0.87), red/processed meat (≥ 74.29 g/day: OR 0.70, 95%CI 0.35, 0.98), protein (≥ 65.05 g/day: OR 0.85, 95%CI 0.30, 0.99), and dietary iron (≥ 8.58 mg/day: OR 0.58, 95%CI 0.35, 0.94) protected against it. Smoking was also associated with a reduction in ID odds (OR 0.34, 95%CI 0.12, 0.99). Baseline BMI, parity, smoking, and diet are associated with ID in early pregnancy in non-anaemic women. Pregnancy planning policies should focus on women at higher risk of ID, such as those who are underweight, multiparous, or following vegetarian diets. This clinical trial was registered at www.clinicaltrialsregister.eu as EudraCT number 2012-005,480-28 and at www.clinicaltrials.gov with identification number NCT03196882.© 2023. The Author(s).
  • Otros:

    Autor según el artículo: Iglesias-Vázquez, L; Gimeno, M; Coronel, P; Caspersen, IH; Basora, J; Arija, V
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Arija Val, Maria Victoria / Basora Gallisa, Josep / Iglesias Vazquez, Lucia
    Palabras clave: Serum ferritin Prenatal Maternal Iron status Iron deficiency Hfe c282y Haemoglobin serum ferritin risk maternal iron status iron deficiency hemochromatosis haemoglobin
    Resumen: Several population-specific genetic, sociodemographic, and maternal lifestyle factors are related to iron status in early pregnancy, and their identification would allow preventive actions to be taken. The study aimed to identify maternal factors associated with iron deficiency (ID) in early pregnancy in non-anaemic pregnant women from a European Mediterranean country. Cross-sectional study using the initial population of the ECLIPSES study performed in non-anaemic pregnant women before gestational week 12. Serum ferritin (SF) and haemoglobin concentrations were measured to evaluate iron status, and ID was defined as SF < 15 µg/L. Several sociodemographic and lifestyle data were recorded and used as covariates in the multivariate-adjusted regression models. Out of the 791 participants, 13.9% had ID in early pregnancy. Underweight (OR 3.70, 95%CI 1.22, 15.53) and parity (1 child: OR 2.03, 95%CI 1.06, 3.88; ≥ 2 children: OR 6.96, 95%CI 3.09, 15.69) increased the odds of ID, while a high intake of total meat (≥ 108.57 g/day: OR 0.37, 95%CI 0.15, 0.87), red/processed meat (≥ 74.29 g/day: OR 0.70, 95%CI 0.35, 0.98), protein (≥ 65.05 g/day: OR 0.85, 95%CI 0.30, 0.99), and dietary iron (≥ 8.58 mg/day: OR 0.58, 95%CI 0.35, 0.94) protected against it. Smoking was also associated with a reduction in ID odds (OR 0.34, 95%CI 0.12, 0.99). Baseline BMI, parity, smoking, and diet are associated with ID in early pregnancy in non-anaemic women. Pregnancy planning policies should focus on women at higher risk of ID, such as those who are underweight, multiparous, or following vegetarian diets. This clinical trial was registered at www.clinicaltrialsregister.eu as EudraCT number 2012-005,480-28 and at www.clinicaltrials.gov with identification number NCT03196882.© 2023. The Author(s).
    Áreas temáticas: Saúde coletiva Química Odontología Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar Hematology General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: josep.basora@urv.cat lucia.iglesias@urv.cat josep.basora@urv.cat victoria.arija@urv.cat
    Identificador del autor: 0000-0001-7131-4144 0000-0002-1758-0975
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://link.springer.com/article/10.1007/s00277-023-05123-7
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Annals Of Hematology. 102 (4): 741-748
    Referencia de l'ítem segons les normes APA: Iglesias-Vázquez, L; Gimeno, M; Coronel, P; Caspersen, IH; Basora, J; Arija, V (2023). Maternal factors associated with iron deficiency without anaemia in early pregnancy: ECLIPSES study. Annals Of Hematology, 102(4), 741-748. DOI: 10.1007/s00277-023-05123-7
    DOI del artículo: 10.1007/s00277-023-05123-7
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Hematology,Medicine (Miscellaneous)
    Serum ferritin
    Prenatal
    Maternal
    Iron status
    Iron deficiency
    Hfe c282y
    Haemoglobin
    serum ferritin
    risk
    maternal
    iron status
    iron deficiency
    hemochromatosis
    haemoglobin
    Saúde coletiva
    Química
    Odontología
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Hematology
    General medicine
    Farmacia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
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