Autor según el artículo: Khoury, N; Martínez, MA; Paz-Graniel, I; Martínez-González, MA; Corella, D; Castañer, O; Martínez, JA; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, JL; Bueno-Cavanillas, A; Tur, JA; Sanjurjo, SC; Pintó, X; Gaforio, JJ; Matía-Martín, P; Vidal, J; Vázquez, C; Daimiel, L; Ros, E; Sayon-Orea, C; Sorlí, JV; Pérez-Vega, KA; Garcia-Rios, A; Bellvert, NG; Gómez-Gracia, E; Zulet, MA; Chaplin, A; Casas, R; Salcedo-Bellido, I; Tojal-Sierra, L; Bernal-Lopez, MR; Vázquez-Ruiz, Z; Asensio, EM; Goday, A; Peña-Orihuela, PJ; Signes-Pastor, AJ; Garcia-Arellano, A; Fitó, M; Babio, N; Salas-Salvadó, J
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Alkhoury, Nadine / Babio Sánchez, Nancy Elvira / Martínez Rodríguez, María Ángeles / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge
Palabras clave: Prospective studies Polychlorinated dibenzodioxins Polychlorinated dibenzo-p-furans (pcdd/f) Polychlorinated dibenzo-p-furans (pcdd Polychlorinated biphenyls Overweight Obesity, abdominal Obesity Middle aged Male Humans General-population Furans Female Endocrine disrupting chemicals Eating Dioxins Dibenzofurans, polychlorinated Dibenzofurans Cross-sectional studies Adiposity Abdominal obesity polychlorobiphenyls pcdd/fs pcbs obesity metabolic syndrome health f) exposure endocrine disrupting chemicals biphenyls adults adiposity adherence abdominal obesity
Resumen: Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55–75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: indiradelsocorro.paz@urv.cat mangeles.martinez@urv.cat nadine.khoury@estudiants.urv.cat indiradelsocorro.paz@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Identificador del autor: 0000-0002-3204-6877 0000-0001-8595-3772 0000-0002-3204-6877 0000-0003-2700-7459 0000-0003-3527-5277
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Environmental Research. 227 115697-
Referencia de l'ítem segons les normes APA: Khoury, N; Martínez, MA; Paz-Graniel, I; Martínez-González, MA; Corella, D; Castañer, O; Martínez, JA; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Romag (2023). Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status.. Environmental Research, 227(), 115697-. DOI: 10.1016/j.envres.2023.115697
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV