Beyond aldehydes and ketones - Novel methodology for catalytic reductive amination

Identifier:  TFG:10084

Handle: https://hdl.handle.net/20.500.11797/TFG10084

Authors:  Bigorra Papiol, Joan

Abstract:
The synthesis of amines is crucial for drug development due to their biological and pharmacological activity. Several transformations have been established for their synthesis, with reductive amination being one of the most used. A novel method to access the products of reductive amination has been developed using esters, in place of the aldehydes typically used, and sustainable catalysis. Lewis acid catalysts were found for the direct amidation and a reductive amination of esters with amines in a one- pot transformation using HBpin as the terminal reductant. The optimal Lewis acids were found to be BBr3 and Sc(OTf)3.